Volume : 12, Issue : 01, January – 2025

Title:

PREPARATION AND EVALUATION OF KETOCONAZOLE MICROSPONGE TO IMPROVE THERAPEUTICS EFFECTIVENESS

Authors :

Sakshi Yadav, Ankita Shukla, Naveen Gupta

Abstract :

Microsponges are porous cross-linked polymers, which have the ability to load a wide range of pharmaceutical active ingredients. They are used topically for long-term treatment applications in addition to the oral route of administration. They are characterized by the efficient distribution of active ingredients, which are loaded at a low quantity to release the drug over longer periods of time by altering the release characteristics. The objective of this study was to develop a novel drug-delivery system that included ketoconazole microsponges. For Eudragit based microsponges, the mean particle size was found to increase with the decrease in the polymer amount. The microsponges showed homogenous particle size distribution with three blade centrifugal stirrer. Stirring speed and time has profound effect on particle size and size distribution of microsponges. The increase in the stirring rate resulted in a reduction in mean particle size. The results of loading efficiency showed that the higher drug loading efficiencies were obtained at the higher drug: polymer ratios. The relatively high production yield and loading efficiency of ethanol entrapped styrene microsponges and Eudragit RS100 microsponges indicated that both the methods are suitable for preparing the microsponge formulations. The result concluded that KM2 formulation was best of microspones because of having maximum polymer concentration of Eudragit RS 100 for retarding release of drug in controlled diffusion kinetics.
Keywords: Ketoconazole, Microsponges, Eudragit RS 100, Quasi emulsion solvent diffusion method, controlled diffusion kinetics

Cite This Article:

Please cite this article in press Sakshi Yadav et al., Preparation And Evaluation Of Ketoconazole Microsponge To Improve Therapeutics Effectiveness., Indo Am. J. P. Sci, 2025; 12 (01).

Number of Downloads : 10

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