Volume : 12, Issue : 06, June – 2025

Title:

DEVELOPMENT AND EVALUATION OF HOLLOW MICROSPHERES OF CLARITHROMYCIN FOR GASTROINTESTINAL INFECTION

Authors :

Thirumanikandan M, Karthik T, Rathish Ramankutty*

Abstract :

Gastrointestinal infections caused by pathogens such as Helicobacter pylori, Escherichia coli, and Salmonella present significant health challenges, often requiring prolonged antibiotic therapy. However, conventional oral treatments suffer from issues like poor bioavailability, limited drug concentration at the infection site, and frequent dosing, leading to suboptimal therapeutic outcomes. This study explores the development of hollow microspheres as a novel gastro-retentive drug delivery system (GRDDS) for clarithromycin, a widely used antibiotic. The aim was to enhance the drug’s bioavailability and reduce dosing frequency. Hollow microspheres of clarithromycin were prepared using the emulsion solvent evaporation method with polymers such as Ethyl Cellulose, HPMC K4, and Eudragit S. The prepared microspheres were evaluated for drug encapsulation efficiency, particle size, surface morphology, buoyancy, and drug release profile. The results showed that the microspheres had a good buoyancy with floating lag times ranging from 50 to 80 seconds and total floating times exceeding 8 hours. The in vitro drug release followed zero-order kinetics, with formulation F5 (containing Ethyl Cellulose, HPMC K4, and Eudragit S) achieving 98.64% drug release over 10 hours. The optimized formulation demonstrated stability over a three-month period under accelerated conditions. The hollow microspheres significantly improved the bioavailability and therapeutic efficacy of clarithromycin, offering a promising solution to the limitations of conventional oral antibiotic therapies for gastrointestinal infections.
Keywords: Hollow Microspheres, Clarithromycin, Gastro-retentive Drug Delivery System (GRDDS), Emulsion Solvent Evaporation, Drug Encapsulation, Sustained Release, Bioavailability, In-vitro Release, Floating Tablets, Kinetics.

Cite This Article:

Please cite this article in press Thirumanikandan M et al Development And Evaluation Of Hollow Microspheres Of Clarithromycin For Gastrointestinal InfectionIndo Am. J. P. Sci, 2025; 12(07).

Number of Downloads : 10

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