Volume : 12, Issue : 06, June – 2025

Title:

FORMULATION CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF HERBAL TOPICAL GEL

Authors :

K.Tharun kumar*, Dr.T.Mangilal, Nameera Naureen, Asra Jahan, Bysani Jaswanth, Ayesha Tarannum,Jamgam Sravani

Abstract :

This study aimed to develop and evaluate herbal topical gel formulations with antibacterial properties using ethanolic leaf extracts of Phyllanthus neruri and Heliotropium indicum. These plants were selected for their established antioxidant, anti-inflammatory, and antimicrobial activities. Ethanol was used as the extraction solvent due to its effectiveness in isolating bioactive compounds. Phytochemical screening confirmed the presence of key antibacterial constituents, including flavonoids, phenolics, terpenes, and alkaloids.
Four formulations were prepared using 2% carbopol gel base: F1 (control), F2 (P. neruri extract), F3 (H. indicum extract), and F4 (a 1:1 combination of both). All formulations were evaluated for physical parameters—pH, viscosity, spreadability, and homogeneity—as well as antibacterial efficacy against Staphylococcus aureus and Escherichia coli using the agar well diffusion method.
Among all, F4 exhibited the most significant antibacterial activity, comparable to the standard neomycin sulfate gel, and remained physically and chemically stable under accelerated storage conditions. The findings support the therapeutic potential of these herbal extracts in formulating effective, stable, and natural topical antibacterial gels, offering a promising alternative to synthetic agents with fewer side effects.
Keywords: Phyllanthus neruri, Heliotropium indicum ,Herbal topical gel Antibacterial activity, Ethanolic extract
.

Cite This Article:

Please cite this article in press K.Tharun kumar et al., Formulation Characterization And Antibacterial Evaluation Of Herbal Topical Gel.., Indo Am. J. P. Sci, 2025; 12(07).

Number of Downloads : 10

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