Volume : 12, Issue : 06, June – 2025
Title:
ELECTROSPUN QUERCETIN LOADED NANOFIBER USING PVA AND PEG POLYMER FOR MANAGEMENT OF HYPERTENSION.
Authors :
Jadhavar Nilesh Govind, Dr. Bhusnure O.G., Dr. Mani Ganesh, Lanjile Indrajit, Dr. Hyun Tae Jang, Akash S. Jaybhaye
Abstract :
Purpose: The purpose of this study was to formulate and evaluate QUERCETIN loaded nanofiber to improve bioavailability of quercetin for enhanced solubility. Among the various polymers PVA and PEG was used.
Methods: Nanofibers were prepared by electrospinning method. First, the polymers were selected, and then a suitable solvent was chosen based on the polymer’s solubility. Then respective solvent was used for electrospinning. Different batches of nanofibers were produced based on various ratios. Electrospinning was then performed to obtain these different nanofiber batches. The formulation was optimized using criteria such as lightweight properties, small diameters, controllable pore structures, and a high surface-to-volume ratio. The optimized formulation batch (N-2) was taken and subjected to various thermodynamic studies. It was then evaluated for different characteristics, including FTIR, DSC, XRD, entrapment efficiency, and SEM studies.
Results-Based on the 94 % drug release rate and the good solubility of the nanofiber in PBS Ph 4.5 it was determined that the solubility of the nanofiber is 1.5 times higher than that of pure Quercetin. Nanofibers exhibit a large surface area, porosity, and adaptable surface functions, which could aid in reducing symptoms of hypertension associated with Quercetin by enhancing drug delivery and bioavailability.
Keywords –Electrospinning, Nanofiber, Hypertension, Quercetin.
Cite This Article:
Please cite this article in press Jadhavar Nilesh Govind et al., Studying The Controlled Release Effect Of Various Polymer Carrier On Drug Release.., Indo Am. J. P. Sci, 2025; 12(07).
Number of Downloads : 10
References:
1. Chobanian AV,Bakris GL,Black HR, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: The JNC 7 Report. JAMA 2003;289:2560-72.
2. Kearney PM, Whelton M, Reynolds K, et al. Global burden of hypertension: analysis of worldwide data. Lancet 2005;365:217-23.
3. Thom T, Haase N, Rosamond W, et al. Heart disease and stroke statistics—2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2006;113:85-151.
4. Hoyert DL, Heron M, Murphy SL, et al. Deaths: Final data for 2003. www.cdc.gov/ nchs/products/pubs/pubd/hestats/finaldeaths03/finaldeaths03.htm, 2006.
5. United States Renal Data System. USRDS 2003 Annual Data Report. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, MD, July 31, 2003. Also found at: www.usrds.org, accessed 21 February 06 at 19:28 CST.
6. Vasan RS, Larson MG, Leip EP, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med 2001;345:1291-7.
7. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Prospective Studies Collaborative. Lancet 2002;360:190313.
8. Moore LL, Singer MR, Bradlee ML, et al. Intake of fruits, vegetables, and dairy products in early childhood and subsequent blood pressure change. Epidemiology 2005;16:4 –11
9. Pereira MA, Jacobs DR Jr., Van Horn L, Slattery ML, Kartashov AI, Ludwig DS. Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA study. JAMA 2002;287: 2081–9.
10. Bostick RM, Kushi LH, Wu Y, Meyer KA, Sellers TA, Folsom AR. Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 1999;149:151– 61. 8. Wang L, Manson JE, Buring JE, Lee IM, Sesso HD. Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women. Hypertension 2008;51:1073–
11. S. Ramakrishna, K. Fujihara, W. Teo, T. Lim, Z. Ma, An Introduction to Electrospinning and Nanofibers, World Scientific Publishing Co. Pt. Ltd. (2005).
12. G. Odian, Principles of Polymerization, John Wiley & Sons (2004).
13. M. Ramalingam, S. Ramakrishna, Nanofiber Composites for Biomedical Applications, Wood head Publishing Series, Elsevier (2017).
14. F.K. Ko, Y. Wan, Introduction to Nanofiber Materials, Materials Research Society (2014).
15. N. Bhardwaj, S.C. Kundu, Electrospinning: A fascinating fiber fabrication technique, Biotech. Adv. 28 (2010) 325-347.
16. Z.M Huang, Y.Z Zhang, M. Kotaki, S. Ramakrishna, A review on polymer nanofibers by electrospinning and their applications in nanocomposites, Compos. Sci. Technol. 63 (2003) 2223-2253.
17. C. Kriegel, K.M. Kit, D.J. McClements, Weiss J. Electrospinning of chitosan– poly(ethylene oxide) blend nanofibers in the presence of micellar surfactant solutions, Polymer 50 (2009) 189-200.
18. G. Toskas, C. Cherif, R. Hund, E. Laourine, B. Mahltig, A. Fahmi, C. Heinemann, T. Hanke, Chitosan (PEO)/silica hybrid nanofibers as a potential biomaterial for bone Regeneration, Carbohydr. Polym. 94 (2013) 713-722.
19. Aluigi, C. Vineis, A. Varesano, G. Mazzuchetti, F. Ferrero, C. Tonin, Structure and properties of keratin/PEO blend nanofibres, Eur. Polym. J. 44 (2008) 2465- 2475.
20. Mehrabli, M.R.M. Mojtahedi, A. M. Shoushtari, Investigation on physical properties of textured yarns produced from PP/ LDPE blends. J. Eng. Fiber Fabr. 9 (2014) 135-139.
21. M. Krištofič, A. Ujhelyiová, Compatibilisation of PP/PA Blends, Fibres Text East Eur. 20 (2012) 30-36.
22. J. Vonch, A. Yarin, and C. M. Megaridis, Electrospinning: A study in the formation of nanofibers, Am. J. Undergrad. Res. 1 (2007).
23. Frenot, I.S. Chronakis, Polymer nanofibers assembled by electrospinning, Curr. Opin. Colloid Interface Sci. 8 (2003) 64-75.
24. Haider, S. Haider, I.K. Kang, A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology, Arab. J. Chem. 11 (2018) 1165-1188.
25. S. Thenmozhi, N. Dharmaraj, K. Kadirvelu, H. Y. Kim, Electrospun nanofibers: New generation materials for advanced applications, Mat. Sci. and Eng. B 217 (2017) 36-48.
26. T. Uyar, E. Kny, Electrospun Materials for Tissue Engineering and Biomedical Applications, Woodhead Publishing, UK (2017) 1-38. 38
27. B. Ding, J. Yu, Electrospun Nanofibers for Energy and Environmental Applications, Springer (2014) 355-369.
28. R. Augustine, H.N. Malik, D.K. Singhal, A. Mukherjee, D. Malakar, N. Kalarikkal, S. Thomas, Electrospun polycaprolactone/ZnO nanocomposite membranes as biomaterials with antibacterial and cell adhesion properties, J. Polym. Res. 21 (2014) 347-363.
29. P. Harikrishnan, A. Sivasamy, Preparation, characterization of electrospun polycaprolactone-nano zinc oxide composite scaffolds for osteogenic applications, Nano-Struct. Nano-Objects 23 (2020) 100518-100525.
30. J.B. Branco, A.C. Ferreira, T.A. Gasche, J.P. Leal, Electrospun lanthanide bimetallic oxide nanoparticles and nanofibers for partial oxidation of methane, Nano-Struct. Nano-Objects 15 (2018) 75-83.
31. K. Aruchamy, A. Mahto, S.K. Nataraj, Electrospun nanofibers, nanocomposites and characterization of art: Insight on establishing fibers as product, Nano-Struct. Nano-Objects 16 (2018) 45-58.
32. P. Raghavan, D. Lim, J. Ahn, C. Nah, D.C. Sherrington, H. Ryu, H. Ahn, Electrospun polymer nanofibers: The booming cutting-edge technology, React. Funct. Polym. 72 (2012) 915-930.
33. K. Bicy, S. Suriyakumar, P. Anu Paul, A.S. Anu, N. Kalarikkal, A.M. Stephen, V.G. Geethamma, D. Rouxel, S. Thomas, Highly lithium ion conductive, Al2O3 decorated electrospun P(VDF-TrFE) membranes for lithium-ion battery separators, New J. Chem. 42 (2018) 19505-19520.
34. R. Arumugam, E.S. Srinadhu, B. Subramanian, S. Nallani, β-PVDF based electrospun nanofibers – A promising material for developing cardiac patches, Med. Hypotheses 122 (2019) 31-34.
35. Haider, S. Haider, I.K. Kang, A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology, Arab. J. Chem. 11 (2018) 1165-1188.
36. S. Thenmozhi, N. Dharmaraj, K. Kadirvelu, H. Y. Kim, Electrospun nanofibers: New generation materials for advanced applications, Mat. Sci. and Eng. B 217 (2017) 36-48.
37. T. Uyar, E. Kny, Electrospun Materials for Tissue Engineering and Biomedical Applications, Woodhead Publishing, UK (2017) 1-38. 38
38. B. Ding, J. Yu, Electrospun Nanofibers for Energy and Environmental Applications, Springer (2014) 355-369.
39. R. Augustine, H.N. Malik, D.K. Singhal, A. Mukherjee, D. Malakar, N. Kalarikkal, S. Thomas, Electrospun polycaprolactone/ZnO nanocomposite membranes as biomaterials with antibacterial and cell adhesion properties, J. Polym. Res. 21 (2014) 347-363.
40. P. Harikrishnan, A. Sivasamy, Preparation, characterization of electrospun polycaprolactone-nano zinc oxide composite scaffolds for osteogenic applications, Nano-Struct. Nano-Objects 23 (2020) 100518-100525.