Volume : 12, Issue : 06, June – 2025

Title:

CAFFEINE CONSUMPTION DURING PREGNANCY: SYSTEMATIC REVIEW OF IMPACTS ON NEONATAL OUTCOMES

Authors :

Jawharah Radhi ALAhmed, Khalil Ibrahim Bograin, Dana Mohammed Akram Motabagani, Rahma Khalid Aljeri, Rawan Mohammed Alhubail, Ghaliah Ibrahim Alnowis, Reem Ahmed Ali Almusalam, Fatimah Taher Aljasem, Atheer Khalid Ahmed Al-Mutairi, Mariya Mohammed Alarfaj, Jumanah Abdulaziz Almas

Abstract :

Objectives: to assess and compile the available data on the relationship between a mother’s caffeine intake during pregnancy and the outcomes of her unborn child. Methods: A comprehensive search of four databases led to the discovery of 832 relevant publications. Five studies were finally chosen based on the inclusion criteria after 36 full-text papers were reviewed, duplicates were removed using Rayyan QCRI, and each article was evaluated for relevance. Results: Five trials totaling 82,503 pregnant women were involved. Findings across studies varied. High caffeine consumption has not been linked to negative consequences like low birth weight or premature birth, according to some reports. However, even when the mother’s caffeine intake stayed below 200 mg/day, several studies found a significant correlation between moderate to high caffeine consumption, particularly during the first trimester, and an increased risk of SGA infants. No consistent relationship was found with neonatal anthropometric parameters. Conclusion: Although current recommendations state that consuming less than 200 mg of caffeine per day is safe, evidence indicates that even moderate prenatal exposure may increase the risk of SGA. These findings suggest a need to re-evaluate existing recommendations and support enhanced prenatal dietary counseling to promote fetal health.
Keywords: Caffeine, Pregnancy, Neonatal outcomes, Birth weight, Preterm birth, Maternal diet, Fetal development.

Cite This Article:

Please cite this article in press Jawharah Radhi ALAhmed et al., Caffeine Consumption During Pregnancy: Systematic Review Of Impacts On Neonatal Outcomes.., Indo Am. J. P. Sci, 2025; 12(07).

Number of Downloads : 10

References:

1. Cappelletti S, Piacentino D, Sani G, Aromatario M. Caffeine: cognitive and physical performance enhancer or psychoactive drug? [published correction appears in Curr Neuropharmacol. 2015;13(4):554. Daria, Piacentino[corrected to Piacentino, Daria]]. Curr Neuropharmacol. 2015;13(1):71-88. doi:10.2174/1570159X13666141210215655
2. Qian J, Chen Q, Ward SM, Duan E, Zhang Y. Impacts of Caffeine during Pregnancy. Trends Endocrinol Metab. 2020;31(3):218-227. doi:10.1016/j.tem.2019.11.004
3. Lakin H, Sheehan P, Soti V. Maternal Caffeine Consumption and Its Impact on the Fetus: A Review. Cureus. 2023;15(11):e48266. Published 2023 Nov 4. doi:10.7759/cureus.48266
4. Institute of Medicine (US) Committee on Understanding Premature Birth and Assuring Healthy Outcomes; Behrman RE, Butler AS, editors. Preterm Birth: Causes, Consequences, and Prevention. Washington (DC): National Academies Press (US); 2007. 10, Mortality and Acute Complications in Preterm Infants. Available from: https://www.ncbi.nlm.nih.gov/books/NBK11385/
5. Brent RL, Christian MS, Diener RM. Evaluation of the reproductive and developmental risks of caffeine. Birth Defects Res B Dev Reprod Toxicol. 2011;92(2):152-187. doi:10.1002/bdrb.20288
6. Zhang R, Manza P, Volkow ND. Prenatal caffeine exposure: association with neurodevelopmental outcomes in 9- to 11-year-old children. J Child Psychol Psychiatry. 2022;63(5):563-578. doi:10.1111/jcpp.13495
7. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. International journal of surgery. 2021 Apr 1;88:105906.
8. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Systematic reviews. 2016 Dec;5:1-0.
9. Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, Henry D, Altman DG, Ansari MT, Boutron I, Carpenter JR. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. bmj. 2016 Oct 12;355.
10. Kukkonen A, Hantunen S, Voutilainen A, Ruusunen A, Backman K, Kirjavainen PV, Ylilauri M, Voutilainen R, Pasanen M, Keski-Nisula L. Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort. Archives of Gynecology and Obstetrics. 2024 Jul;310(1):359-68.
11. Vitti FP, Grandi C, Cavalli RD, Simões VM, Batista RF, Cardoso VC. Association between caffeine consumption in pregnancy and low birth weight and preterm birth in the birth Cohort of Ribeirão Preto. Revista Brasileira de Ginecologia e Obstetrícia. 2018 Dec;40(12):749-56.
12. Okubo H, Miyake Y, Tanaka K, Sasaki S, Hirota Y. Maternal total caffeine intake, mainly from Japanese and Chinese tea, during pregnancy was associated with risk of preterm birth: the Osaka Maternal and Child Health Study. Nutrition Research. 2015 Apr 1;35(4):309-16.
13. Wierzejska R, Jarosz M, Wojda B. Caffeine intake during pregnancy and neonatal anthropometric parameters. Nutrients. 2019 Apr 9;11(4):806.
14. Modzelewska D, Bellocco R, Elfvin A, Brantsæter AL, Meltzer HM, Jacobsson B, Sengpiel V. Caffeine exposure during pregnancy, small for gestational age birth and neonatal outcome–results from the Norwegian Mother and Child Cohort Study. BMC pregnancy and childbirth. 2019 Dec;19:1-1.
15. Soltani S, Askari M, Larijani B, Azadbakht L, Esmaillzadeh A. Careful data extraction in meta-analysis: the case of maternal caffeine intake during pregnancy and low-birth weight, childhood overweight, and obesity. International Journal of Obesity. 2021 Apr;45(4):713-4.
16. Rohweder R, de Oliveira Schmalfuss T, dos Santos Borniger D, Ferreira CZ, Zanardini MK, Lopes GP, Barbosa CP, Moreira TD, Schuler-Faccini L, Sanseverino MT, da Silva AA. Caffeine intake during pregnancy and adverse outcomes: An integrative review. Reproductive Toxicology. 2024 Jan 1;123:108518.
17. Rhee J, Kim R, Kim Y, Tam M, Lai Y, Keum N, Oldenburg CE. Maternal caffeine consumption during pregnancy and risk of low birth weight: a dose- response meta-analysis of observational studies. PloS one. 2015 Jul 20;10(7):e0132334.
18. Aldridge A, Bailey J, Neims AH. The disposition of caffeine during and after pregnancy. Semin Perinatol. 1981;5(4):310–4. Epub 1981/10/01. pmid:7302604.
19. Tassaneeyakul W, Birkett DJ, McManus ME, Veronese ME, Andersson T, Tukey RH, et al. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem Pharmacol. 1994;47(10):1767–76. Epub 1994/05/18. pmid:8204093.
20. 4Tsutsumi K, Kotegawa T, Matsuki S, Tanaka Y, Ishii Y, Kodama Y, et al. The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N- acetyltransferase activities in humans. Clin Pharmacol Ther. 2001;70(2):121–
5. Epub 2001/08/15. pmid:11503005.
21. Infante-Rivard C. Caffeine intake and small-for-gestational-age birth: modifying effects of xenobiotic-metabolising genes and smoking. Paediatr Perinat Epidemiol. 2007;21(4):300–9. Epub 2007/06/15. pmid:17564586.
22. Brent RL, Christian MS, Diener RM. Evaluation of the reproductive and developmental risks of caffeine. Birth Defects Res B Dev Reprod Toxicol.
2011;92(2):152–87. Epub 2011/03/04. pmid:21370398; PubMed Central PMCID: PMC3121964.
23. Goldstein A, Warren R. Passage of caffeine into human gonadal and fetal tissue. Biochem Pharmacol. 1962;11:166–8. Epub 1962/02/01. pmid:13899873.
24. Aldridge A, Aranda JV, Neims AH. Caffeine metabolism in the newborn. Clin Pharmacol Ther. 1979;25(4):447–53. Epub 1979/04/01. pmid:428190.
25. Daly JW. Alkylxanthines as research tools. J Auton Nerv Syst. 2000;81(1– 3):44–52. Epub 2000/06/28. pmid:10869699.
26. Momoi N, Tinney JP, Keller BB, Tobita K. Maternal hypoxia and caffeine exposure depress fetal cardiovascular function during primary organogenesis. J Obstet Gynaecol Res. 2012;38(12):1343–51. Epub 2012/05/23. pmid:22612345; PubMed Central PMCID: PMC3427416.
27. Bistoletti P, Fredholm BB, Lagercrantz H. Cyclic 3′,5′-adenosine monophosphate in umbilical cord blood of the newborn infant: relation to fetal stress and plasma catecholamines. Biol Neonate. 1981;40(3–4):145–9. Epub 1981/01/01. pmid:6269661.