Volume : 12, Issue : 06, June – 2025
Title:
A STUDY ON RELEASE BEHAVIOR OF NATURAL AND SYNTHETIC POLYMERS
Authors :
Ambrish B Kantikar, Dr.Abdul Sayeed, Md Ather Ahmed Abid,Shakeel Ahmed Siddiqui
Abstract :
In the pharmaceutical dosage forms several approaches are available to include the loading dose of a drug to the maintenance dose of a drug for sustained action. A novel approach for having the loading dose and maintenance dose in a tablet is the formulation of drugs in Matrix tablets. By using Matrix tablet system, it makes possible to design extended release preparation with an immediate release quantity in one layer and extended release proportion in the second, thus maintaining a prolong blood level.
Aceclofenac is belongs to the category of non-steroidal anti-inflammatory drugs (NSAIDs), which has the biological half-life 2-4 hrs, and bioavailability of 15 %, so attempt to make Aceclofenac bi-layer matrix tablets to sustained the drug release for extended period of time.
In the present work an attempt has been made to prepare matrix tablets of aceclofenac in which one layer was sustained release layer and other layer was immediate release layer. The sustained release layer was made by using various synthetic and natural polymers.
The synthetic polymers CMC, HPMC and natural polymer delonix regia seed gum (DRSG) were used in the different concentrations. All the tablets were prepared by wet granulation method. The prepared granules and tablets were evaluated for various pre compression and post compression parameters like angle of repose, bulk density, tapped density, hausner’s ratio,carr’s index, hardness, thickness, weight variation, drug content, in-vitro drug release, drug-polymer interaction by IR and DSC studies and short term stability study. The prepared tablets showed the hardness between 6.5±0.10 kg/cm2 and 7.0±0.30 kg/cm2,weight variation in the range 307±0.58 mg to 326 ±0.23 mg which is below ±7.5%, friability below >1% and drug content in between 95.51±1.75 to100.03 ±1.23%. All the formulations displayed zero order release kinetics ‘r’ values from 0.926 to 0.998 for all the formulations. Higuchi and Peppas data reveals that the drug released by non – fickian diffusion mechanisms.
In-vitro drug release study shows near about 21 % drug release within first two hrs. because of immediate release layer and 99.25%, 98.34% and 98.7 % drug release at the last of 24th hr. in the formulation AHII, ADI and AHC which contains 40%HPMC, 30% Delonix regia seed gum and 24%HPMC and 24% DRS gum respectively, which found to be most promising.
From the IR and DSC studies results reveals that there is no interaction between drug and any excipients. Stability study results reveals that there is no change in the drug content in the prepared tablets.
Keywords: Matrix tablets, Aceclofenac, CMC, HPMC, Delonix regia seed gum.
Cite This Article:
Please cite this article in press Ambrish B Kantikar et al .,A Study On Release Behavior Of Natural And Synthetic Polymers.., Indo Am. J. P. Sci, 2025; 12(07).
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