Volume : 12, Issue : 06, June – 2025
Title:
FORMULATION AND CHARACTERIZATION OF DOCETAXEL NANOEMULSION
Authors :
D. Srilatha*, Dr. CH. Kantlam, M. Navya, John, Kutejnaaz, M. Naresh, N. Sriya
Abstract :
The objective of the present study was to develop and characterize an optimal stable Nano emulsion formulation of Docetaxel with an aim to increase its bioavailability. The components for the formulation of Nano emulsion were olive and olive oil selected as the oil phase, surfactants namely span20 and the co-surfactants, Ethanol were selected. Different concentrations of oil and surfactant, which formed nanoemulsions were selected based on the thermodynamic stability and dispersibility test. Optimized formulation was selected for in vitro study on the basis of higher drug release, optimum globule size, minimum lower viscosity, and overall lower surfactant concentration and co-surfactant. The diffusion of drug from nanoemulsion was compared with marketed formulation and we obtained better result from it. Thus nanoemulsion could be used effectively to improve the bioavailability of poorly water soluble drugs to improve their bioavailability. The nanoemulsion were optimized optical transparency, viscosity measurement, phase separation determination of pH, measurement of globule size, zeta potential, drug content, in vitro diffusion study, stability study.
Keywords: Docetaxel, FTIR studies, oils, surfactants, Co-surfactants, In vitro drug release studies
Cite This Article:
Please cite this article in press D. Srilatha et al., Formulation And Characterization Of Docetaxel Nanoemulsion., Indo Am. J. P. Sci, 2025; 12(07).
Number of Downloads : 10
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