Volume : 12, Issue : 06, June – 2025
Title:
FORMULATION AND OPTIMIZATION OF FLOATING BILAYER TABLETS FOR MANAGEMENT OF BACTERIAL INFECTION
Authors :
Manjit Kumar Roy and Ganesh Prasad Patel
Abstract :
The therapeutic area in which gastroretentive floating drug delivery system (FDDS) can be explored is the eradication of Helicobacter pylori (H. pylori), which is now believed to be the causative bacterium for chronic gastritis and peptic ulcers. Although the bacterium is highly sensitive to most antibiotics, its eradication from patients requires high concentrations of drug be maintained within the gastric mucosa for a long duration. H. pylori cause’s gastric diseases, such as peptic ulcer, gastric mucosa associated lymphoma. One reason for the incomplete eradication of H. pylori is probably due to the short residence time of antimicrobial agents in the stomach so that effective antimicrobial concentration cannot be achieved in the gastric mucous layer or epithelial cell surfaces where H. pylori exist.
Keywords: Floating Drug Delivery, Bilayer tablet, Bacterial infection, H. pylori, Multiparticulate systems
Cite This Article:
Please cite this article in press Manjit Kumar Roy et al., Formulation And Optimization Of Floating Bilayer Tablets For Management Of Bacterial Infection., Indo Am. J. P. Sci, 2025; 12(07).
Number of Downloads : 10
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