Volume : 12, Issue : 06, June – 2025
Title:
DEVELOPMENT AND CHARACTERIZATION OF CISPLATIN-LOADED NEOSOMES FOR TARGETED DRUG DELIVERY
Authors :
J. Prathyusha, Gudigopuram Deepthi, G. Lavanya, D. Vasanth Kumar, E. Poojitha, J Bhupesh
Abstract :
The present study was focused on formulating and evaluating Cisplatin containing niosomal formulation for in vitro studies. Niosomal formulations were prepared by using different ratio of surfactant (Tweens and Spans grades 20, 20) and cholesterol by the thin film hydration method and were evaluated for in vitro characteristics, stability studies. Span 20 containing niosomal formulation displayed highest entrapment efficiency with desired particle size. SEM analyses showed that niosomal formulation was spherical in shape. Niosomes containing Span 20 displayed higher percentage of drug release after 8 h as compared to other formulations. F-4 formulation was found to be stable at the end of the study on storage condition. The present study suggested that niosomal formulations provide sustained and prolonged delivery of drug with enhance bioavailability.
Keywords: niosomes, Cisplatin, bioavailability, thin film hydration technique, in vitro drug release studies
Cite This Article:
Please cite this article in press J. Prathyusha et al Development And Characterization Of Cisplatin-Loaded Neosomes For Targeted Drug Delivery., Indo Am. J. P. Sci, 2025; 12(07).
Number of Downloads : 10
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