Volume : 12, Issue : 06, June – 2025
Title:
DEVELOPMENT AND EVALUATION OF ENHANCED GASTRIC RETENTION OF LEVOFLOXACIN USING FLOATING MICROSPHERES
Authors :
Gudigopuram Deepthi, J. Prathyusha, B. Madhumitha, M. Madhulatha, K.Sneha Reddy, J. Mahendar
Abstract :
Levofloxacin floating microspheres were formulated and characterized for enhancing residence time of drug in GIT. Levofloxacin is a fluoroquinolone antibiotic. Floating microspheres of Levofloxacin with Hpmc, Sodium alginate were prepared by solvent evaporation method. Microspheres were characterized for their micromeritic properties, floating behavior, entrapment efficiency, scanning electron microscopy (SEM), in vitro drug release. Floating microspheres were successfully prepared by solvent evaporation method. SEM images showed that microspheres prepared with different concentrations of polymer and emulsifier were spherical shaped with a smooth surface. The prepared microspheres also showed good flow properties. Microspheres were capable to float for 8 h. As the polymer concentration increases in vitro drug release was decreased. However, the release was controlled by polymer concentration for a longer period. The optimized formulation showed good results for all the evaluation parameters. Hence, it can be concluded that the developed formulation is a potential dosage form for Levofloxacin.
Key words: Levofloxacin, floating microspheres ,Polymers, Invitro kinetic studies.
Cite This Article:
Please cite this article in press Gudigopuram Deepthi et al., Development And Evaluation Of Enhanced Gastric Retention Of Levofloxacin Using Floating Microspheres., Indo Am. J. P. Sci, 2025; 12(07).
Number of Downloads : 10
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