Volume : 12, Issue : 06, June – 2025
Title:
A NOVEL APPROACH FOR MUCOADHESIVE BUCCAL FILM OF NARATRIPTAN
Authors :
Vogoti Jhansilaxmi, Jyothi Muddagoni, B.Manoghna, J.Neeraja, Sravani Singh, B.Sravani
Abstract :
The present investigation is concerned with the development of buccal mucoadhesive patches. Naratriptan is used for acute migraine attacks, which were designed to prolong the residence time and thus to improve the bioavailability of the drug and its half-life. Hydroxy propyl methyl cellulose (HPMC) is one of the polymers which is having good mucoadhesive properties. Therefore, various formulations were developed by using release rate controlling and gel forming polymers like HPMC K and Ethyl cellulose by the solvent casting method. In addition to this, glycerol and DMSO were used as a plasticizer and permeation enhancer respectively. All the formulations had good physical appearance and physicochemical properties. From among all the developed formations, since formulation F2 retarded the drug release in a controlled manner for prolonged period of more than 6 h, gave satisfactory bioadhesion for maximum duration of 6 h and drug diffused up to the 80%, so it was selected as the best formulation. Swelling studies indicated significant water uptake and contributed in drug release. The most satisfactory formulation had showed no significant change in physicochemical properties, drug content, bio adhesion properties, in vitro diffusion pattern after storage at 30 ± 2ºC (65% RH) and at 40 ± 2ºC (75% RH) during stability studies for 3months as per ICH guidelines. Thus, best formulation satisfied physicochemical parameters, in vitro bioadhesion strength, in vitro drug release and requirements for a buccal mucoadhesive drug delivery system.
Key words: Buccal delivery system, Naratriptan, polymers, solvent casting technique, Mucoadhesive patches, In-vitro release studies.
Cite This Article:
Please cite this article in press Vogoti Jhansilaxmi et al., A Novel Approach For Mucoadhesive Buccal Film Of Naratriptan., Indo Am. J. P. Sci, 2025; 12(07).
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