Volume : 12, Issue : 06, June – 2025

Title:

DESIGN AND EVALUATION OF SUSTAINED RELEASE TABLETS OF ROPINIROLE HYDROCHLORIDE

Authors :

Jyothi Muddagoni, Jhansi laxmi Vogoti, S.Ragavendar, Md Nazim Ahmed, B.Sharanya , T.Saraswathi

Abstract :

The sustained release drug delivery is the drug delivery system that achieves the release of drug in the proper amount at regular time interval over an extended period of time and is time independent. The aim of present work was to formulate and evaluate sustained release tablets of Ropinirole using polymers in order to reduce the various side effects associated with Ropinirole as well as to overcome the manufacturing difficulties. For formulating sustained release drug delivery system, synthetic hydrophilic polymers are used. Tablets were prepared by direct compression method using different drug-polymer concentration. FT-IR study revealed that there was no chemical interaction between the drug and polymers used. Pre-compression and post-compression parameters complied with Pharmacopoeial limit for the tablets. The in vitro release study was performed and the results indicated that the formulation F2 was found to be the optimized formulation which can extend the release up to a period of 8 hours.From the stability studies it was clear that the formulation was stable after 3 months at accelerated condition of 400C±20C/75% RH±5% in a stability chamber.
Keywords: Ropinirole , FTIR studies, Synthetic polymers, Direct compression technique, In vitro drug release studies

Cite This Article:

Please cite this article in press Jyothi Muddagoni et al., Design And Evaluation Of Sustained Release Tablets Of Ropinirole Hydrochloride., Indo Am. J. P. Sci, 2025; 12(07).

Number of Downloads : 10

References:

1. Gupta PK and Robinson JR. Oral controlled release delivery. Treatise on controlled drug delivery. 1992;93(2):545-555.
2. Jantzen GM and Robinson JR. Sustained and Controlled- Release Drug Delivery systems. Modern Pharmaceutics. 1995; 121(4): 501-502.
3. Altaf AS, Friend DR, MASRx and COSRx Sustained-Release Technology in Rathbone MJ, Hadgraft J, and Robert MS. Modified Release Drug Delivery Technology, Marcel Dekker Inc., New York, 2003; 126: 996.
4. Gwen MJ and Joseph RR, In Banker GS and Rhodes CT, Eds. Modern Pharmaceutics, Marcel Dekker Inc. New York, 1996; 72(3): 575.
5. Salsa T, Veiga F and Pina ME. Oral controlled release dosage form. I. cellulose ether polymers in hydrophilic matrices. Drug Develop. Ind. Pharm. 1997; 23: 929-938.
6. Wani MS et al. Controlled Release system-A Review. Pharmaceutical Reviews. 2008; 6(1): 41-46.
7. Altaf AS, Friend DR, MASRx and COSRx Sustained-Release Technology in Rathbone MJ, Hadgraft J, Robert MS, Modified Release Drug Delivery Technology, Marcell Dekker Inc., New York, 2003. JPSBR: Volume 1, Issue 3: Nov Dec 2011 (143-151) Patel H. 151
8. Vidyadhara S, Rao PR, Prasad JA. Formulation And Evaluation Of Propranolol Hydrochloride Oral Controlled Release Matrix Tablets. Indian J.Pharm Sci, 2004; 66: 188-192.
9. Reddy KR, Mutalik S, Reddy S. Once-daily sustained release matrix tablets of Nicorandil: Formulation and in vitro evaluation,AAPS Pharm. Sci. Tech.,2003; 4: 1-9.
10.Mohammed AD, James LF, Michael HR, John EH, Rajabi-Siahboomi AR. Release of Propranolol hydrochloride from matrix tablets containing sodium carboxy methylcellulose and Hydroxy propyl methyl cellulose. Phar. Dev. Tech.,1999; 4: 313-324.
11. Lee BJ, Ryu SG, Cui JH. Formulation and release characteristics of hydroxypropyl methylcellulose matrix tablet containing melatonin. Drug Dev. Ind.Pharm.,1999; 25:
12.Gwen MJ, Joseph RR, In Banker GS and Rhodes CT, Eds., Modern Pharmaceutics, 3rd Edn, Vol. 72, Marcel Dekker Inc. New York, 1996: 575.
13. Jantzen GM, Robinson JR. Sustained and controlle release drug delivery system. In BankerGS, Rhodes CT, editors. Modern pharmaceutics. 3rd edition New york: Marcel dekkerInc; 1996.p.575-09.
14. Chein Y.W. Oral Drug delivery and delivery systems. In: Noveldrug delivery systems. Marcel Dekker, Inc., New York, 2002;50; 3rd edition: 139-96.
15. Vyas S,P, KharRK.Controlled Drug delivery: Concepts andAdvances .Concepts and Advances.1sted.vallabhprakashan,2002,p,156- 189.