Volume : 12, Issue : 06, June – 2025
Title:
A REVIEW ON MULTISTEP SYNTHESIS STRATEGIES OF AZOLE-BASED ANTIBACTERIAL AGENTS
Authors :
Priyanka Mishra
Abstract :
This article reviews current multistep synthesis strategies of azole-based antibacterial agents. In recent years, extensive use of chemical agents in treating different diseases resulted in the development of drug resistance. The war on multidrug resistance has resulted in the most significant loss to the world’s economy. Thus, the expansion of development of novel and potential candidates such as azoles and its derivatives is an escalating area in the field of medicinal chemistry. Azole compounds are increasingly being considered necessary in drug discovery paradigms as a number of them serve as lead compounds for the discovery of potent therapeutic agents. They have been used to treat bacterial, fungal, malarial, viral, and other general infections. They have also been known for their anticancer and anti-inflammatory activities. Their efficacy has been attributed to their electron-rich property, resulting in the formation of non-covalent bonds to the receptor proteins. Current research has given us a significant collection of synthetic strategies in the progress of azole compounds. This review article describes the survey of literature regarding multistep synthetic methods in the preparation of azole-based compounds and their antibacterial properties in the.
Keywords: Antibacterial agents, azole derivatives, multistep synthesis and antifungal agents.
Cite This Article:
Please cite this article in press Priyanka Mishra et al., A Review On Multistep Synthesis Strategies Of Azole-Based Antibacterial Agents., Indo Am. J. P. Sci, 2025; 12(07).
Number of Downloads : 10
References:
1 Z. A. Bhavsar, P. T. Acharya, D. J. Jethava, and H. D. Patel, “Recent Advances in Development ofAnthelmintic Agents: Synthesis and Biological Screening,” Synthetic Communications 50, no. 7 (2020):917–46.
2 M. Wang, K. P. Rakesh, J. Leng, W.-Y. Fang, L. Ravindar, D. Channe Gowda, and H.-L. Qin, “Amino Acids/Peptides Conjugated Heterocycles: A Tool for the Recent Development of Novel Therapeutic Agents,” Bioorganic Chemistry 76, no. 2 (2018): 113–29.
3 A. Shanty, J. E. Philip, E. J. Sneha, M. R. Prathapachandra Kurup, S. Balachandran, and P. V. Mohanan, “Synthesis, Characterization and Biological Studies of Schiff Bases Derived from Heterocyclic Moiety,” Bioorganic Chemistry 70 (2017): 67–73.
4 Prashant Purohit, Mahesh Kumar Kataria. Phytochemicals screening, antioxidant and antimicrobial activity of Carica Papaya leaf extracts. Int J Curr Pharm Sci. 2024 May 15; 16(3):95-98.
5 P.Saraswat,G.Jeyabalan,M.Z.Hassan,M.U.Rahman,andN.K.Nyola,“ChemInformAbstract:Review of Synthesis and Various Biological Activities of Spiro Heterocyclic Compounds Comprising Oxindole and Pyrrolidine Moieties,” ChemInform 47, no. 51 (2016): 1643–64.
6 H. P. Ebrahimi, J. S. Hadi, A. A. Almayah, Z. Bolandnazar, A. G. Swadi, and A. Ebrahimi, “Metal-Based Biologically Active Azoles and b-Lactams Derived from Sulfa Drugs,” Bioorganic & Medicinal Chemistry 24, no. 5 (2016): 1121–31.
7 M. Rafiq, M. Saleem, F. Jabeen, M. Hanif, S.-Y. Seo, S. K. Kang, and K. H. Lee, “Facile Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Substituted Azole Derivatives,” Journal of Molecular Structure 1138, no. 4 (2017): 177–91.
8 T. Ali, S. Abdel-Aziz, S. El-Edfawy, E.-H. Mohamed, and S. Abdel-Kariem, “Cleavage of Diethyl Chromonyla-Aminophosphonate with Nitrogen and Carbon Nucleophiles: A Synthetic Approach and Biological Evaluations of a Series of Novel Azoles, Azines and Azepines Containing a-Aminophosphonate and Phosphonate Groups,” Synthetic Communications 44, no. 24 (2014): 3610–29.
9 M.Thwin,B.Mahmoudi,O.A.Ivaschuk,andQ.A.Yousif,“AnEfficientandRecyclableNanocatalystfor the Green and Rapid Synthesis of Biologically Active Polysubstituted Pyrroles and 1,2,4,5-Tetrasubstituted Imidazole Derivatives,” RSC Advances 9, no. 28 (2019): 15966–75.
10 S. S. Gholap, “Pyrrole: An Emerging Scaffold for Construction of Valuable Therapeutic Agents,” European Journal of Medicinal Chemistry 110, no. 2 (2016): 13–31.
11 Purohit P, kataria MK. Phytochemicals screening, antioxidant and antimicrobial activity of carica papaya leaf extracts. Int j curr pharm sci. 2024 may 15; 16(3):95-98.
12 M. Chan, A. Ahmadi, S. Yao, F. Sato-Kaneko, K. Messer, M. Pu, B. Nguyen, T. Hayashi, M. Corr, D. A. Carson, et al. “Identification of Biologically Active Pyrimido[5,4-b]Indoles That Prolong NF-jB Activation without Intrinsic Activity,” ACS Combinatorial Science 19, no. 8 (2017): 533–43.
13 M. S. Santos, D. C. Fernandes, M. T. Rodrigues Jr., T. Regiani, A. D. Andricopulo, A. L. T. G. Ruiz, D. B. Vendramini-Costa, J. E. de Carvalho, M. N. Eberlin, and F. Coelho, “Diastereoselective Synthesis of Biologically Active Cyclopenta[b]Indoles,” The Journal of Organic Chemistry 81, no. 15 (2016): 6626–39.
14 Prashant Purohit and Harendra Singh Rathore, ISABGOL: A HERBAL REMEDY, World Journal of Pharmaceutical Research, Volume 8, Issue 7, 579-585.
15 Prashant Purohit , Priyanka Mishra and Renu Bhati, Gestational Diabetes Mellitus: An Updated Review, RUHS Journal of Health Sciences, Volume 4 Number 4, October-December 2019, 223-26
16 M. E. M. Zayed and P. Kumar, “Spectroscopic Physicochemical and Photophysical Investigation ofBiologically Active 2-Oxo-Quinoline-3-Carbonitrile Derivative,” Journal of Fluorescence 27, no. 3 (2017): 853–60.
17 X.-M.Chu,C.Wang,W.Liu,L.-L.Liang,K.-K.Gong,C.-Y.Zhao,andK.-L.Sun,“Quinolineand Quinolone Dimers and Their Biological Activities: An Overview,” European Journal of Medicinal Chemistry 161 (2019): 101–17.
18 Prashant Purohit and Himisha Gaur, Lipid Based Nano Particles in Cancer Therapy, Indo American Journal of Pharmaceutical Research, 4(2023).225-29
19 D. Allen, D. Wilson, R. Drew, and J. Perfect, “Azole Antifungals: 35 Years of Invasive Fungal Infection Management,” Expert Review of anti-Infective Therapy 13, no. 6 (2015): 787–98.
20 Prashant Purohit, Mahesh Kumar Kataria. Formulation and Evaluation of Polyherbal Ointment Using Carica Papaya and Leptadenia Pyrotechnica International Journal of Current Pharmaceutical Review and Research 2024; 16(5); 22-27