Volume : 12, Issue : 06, June – 2025
Title:
FORMULATION AND IN VITRO EVALUATION OF BUCCAL TABLETS OF LOSARTAN POTASSIUM
Authors :
Sameena Tahseen
Abstract :
The main objective of the present study was to formulate and evaluate the controlled release buccal tablets of losartan potassium by using carbopol, HPMC K4M, HPMC K15M and chitosan were selected as buccoadhesive polymers on the basis of their matrix-forming properties. The prepared tablets were evaluated for various parameters such as drug content, weight variation, hardness, thickness, friability, swelling studies, microenvironment pH, in vitro drug release studies, mucoadhesion strength and release rate kinetics. Based on the evaluation studies, the formulation BL6 has been considered as an optimised formulation, which showed a higher percentage of drug release, 98.47% and it follows zero-order kinetics with diffusion-controlled release.
Keywords: Losartan potassium, Buccal delivery, Buccoadhesive polymers and Bioadhesion
Cite This Article:
Please cite this article in press Sameena Tahseen et al ., . Formulation and in vitro evaluation of buccal tablets of losartan potassium., Indo Am. J. P. Sci, 2025; 12(07).
Number of Downloads : 10
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