Volume : 12, Issue : 06, June – 2025
Title:
PHARMACOGNOSTICAL, PHYTOCHEMICAL AND WOUND HEALING STUDY ON ETHANOLIC EXTRACT OF LEAF OF XANTHIUM STRUMARIUM. Linn
Authors :
Dr.J. Jaslin Edward., Janani.K.S, Shamlin E. Ashwini, Abi.A, Mathan Kumar.M, Astilin lijo.L, Logesh.L
Abstract :
Background: Wound healing is a multifaceted process involving various stages, including inflammation, tissue regeneration and remodelling. This quest for the effective wound healing agents has led to the exploration of traditional medicine and herbal remedies. Xanthium strumarium, a plant species known for its medicinal properties, has gained attention for its potential benefits in wound healing. This study aims to investigate the wound healing potential of Xanthium strumarium leaf extract.
Materials And Methods: Xanthium strumarium leaves were collected from putheri, kanyakumari district and authenticated by experts. This leaves were then processed into a powder and soxhlet extraction was performed using various solvents including Petroleum ether, Chloroform, Ethyl acetate and 70% Ethanol. The extracts were subsequently formulated into 0.5% and 1% ointments. The wound healing activity of these ointments was assessed in adult male albino rats, with 1% silver sulfadiazine serving as a standard comparison.
Result: The study yielded significant results, demonstrating the wound healing potential of Xanthium strumarium leaf extracts. The 0.5% ointment showed complete wound healing on 15th day, while the 1% ointment achieved the same on the 14th day. In comparison, the standard drug, 1% silver sulfadiazine, healed wounds on the 12th day. Physicochemical analysis and qualitative chemical tests revealed promising results, indicating the presence of bioactive compounds that may contribute to the wound healing properties of Xanthium strumarium.
Conclusion: The findings of this study suggest that Xanthium strumarium leaf extracts posses potential wound healing properties, justifying further research for therapeutic applications. The results demonstrate the efficacy of Xanthium strumarium as a natural remedy for wound healing, highlighting its potential as a valuable resource in traditional medicines.
Keywords: Wounds, Soxhlet apparatus, Animals, Extracts.
Cite This Article:
Please cite this article in press Shamlin E. Ashwini et al., Pharmacognostical, Phytochemical And Wound Healing Study On Ethanolic Extract Of Leaf Of Xanthium Strumarium. Linn, Indo Am. J. P. Sci, 2025; 12(06).
Number of Downloads : 10
References:
1. Mayra Cedilla- Cortezano, Luis Ruben Martinez-Cuevas. etal. Uses of medicinal plants in the process of wound healing: A Literature Review. Journal of Pharmaceuticals. 2024; 17(3): 303.
2. S Guo, LA Dipietro. Factors affecting wound healing. Journal of Dental research. March 2010; 89(3): 219-229.
3. J.M. Reinke, H.Sorg. Wound Repair and Regeneration. European Surgical Research. 2012; 49: 35-43.
4. Wenxiang Fan, Linhong Fan, etal. Traditional uses, Botany, Phytochemistry,
Pharmacology, Pharamocokinetics and Toxicology of Xanthium Strumarium L.: A Review. Molecules. 2019; 24: 359.
5. Bhogaonkar P.Y, S A. Ahmad. Pharmacognostic studies on xanthium strumarium L- A Folk unani medicinal herb. Bioscience discovery. January 2012; 3(1): 101-106.
6. Gajanan D. Wadankar, Janhavi J. Bakal, etal. Phytochemical screening of xanthium strumarium and Argemone Mexicana. International Journal of Advanced Research in Biological Sciences. 2022; 9(5): 83-92.
7. Ghulam Hussain. Soxhlet Extraction Principal, Working & Usage. Lab Chemistry & Solutions. 27 July 2023.
8. Swati Trivedi, Vishal Gupta, etal. Phytochemicals & Pharamacological activity of Xanthium strumarium: An Updated Review. Journal of advanced Zoology. 2023; 44(3): 1212 -1221.
9. Chavan S.T. & A.U. Kulkarni. Morphological and Phytochemical Studies on Xanthium strumarium L. Plantae Scientia- An International Research Journal in Botany. November 2021; 4(6): 287-290.
10. Karthick.M, Jeyasekhar.M. P, Jaslin Edward.J. Mangifera Indica Leaves extract confers: Wound healing and antioxidant activity. Asian journal of research in pharmaceutical sciences and biotechnology. 2020; 8(3): 110-116.
11. Prasanth A.R, Jaslin Edward.J. etal. Evaluation of Hepatoprotective activity of the extract vicoa Indica (L) against CCL4_ Induced Hepatotoxicity in albino wistar rats. Indo American Journal of Pharmaceutical science. 2020; 7(12): 2636-2641.
12. Abdollan Ghasemi Pirbalouti etal. Wound healing activity of Malva Sylvestris and Punica Granatum in Alloxan- induced diabetic rats. Natural Drug. 2010; 67(5): 511-516.