Volume : 12, Issue : 03, March – 2025

Title:

PHYTOCONSTITUENTS AND PHARMACOLOGICAL ACTIVITY OF POTENTIAL PLANT MURRAYA KOENIGII
‬

Authors :

Gopal M.Mahale, Yashkumar R.Dhole, Swati P. Deshmukh

Abstract :

Murraya koenigii relates to the Rutaceae family and has many health benefits. To date,over eighty-eight carbazole alkaloids along with terpenoids, and other nutrients have been identified from different parts of this plant. This review presents accumulated information regarding the role of Murraya koenigii and its constituents in the prevention/treatment of cancer.Literature survey revealed that Murraya koenigii and its constituents target multiple deranged pathways associated with apoptosis, growth and cell cycle in a variety of cancerous cell lines (colon, lung, liver, skin, prostate, breast, etc.) and few animal models. Thus, the present review highlights the anticancer mechanism of Murraya koenigii and its phytoconstituents, and further future perspectives. The ameliorating effects of MK and its phytoconstituents against various cancers warrant its multi-institutional clinical trials as soon as possible. The prospects of relatively cheaper cancer drugs could then be brighter, particularly for the socioeconomically feebler cancer patients of the world (1).
Keywords: Murraya koenigii, cytotoxic activity, Herbal medicine ,

Cite This Article:

Please cite this article in press Yashkumar R.Dhole et al., Phytoconstituents And Pharmacological Activity Of Potential Plant Murraya Koenigii., Indo Am. J. P. Sci, 2025; 12 (03)

Number of Downloads : 10

References:

1.Kumar, A., & Sharma, V. (2018). “Phytochemical and pharmacological properties of Murraya koenigii: A review.” Pharmacognosy Reviews, 12(24), 69-75. doi:10.4103/pr.pr_29_18
2. Bhat, A. R., et al. (2020). “Anticancer potential of Murraya koenigii: A comprehensive review.” Journal of Ethnopharmacology, 251, 112551. doi:10.1016/j.jep.2019.112551
3. Mishra, S. K., & Tiwari, M. (2019). “Exploring the cytotoxicity of Murraya koenigii extracts on cancer cells.” Asian Pacific Journal of Cancer Prevention, 20(3), 845-852. doi:10.31557/APJCP.2019.20.3.845
4. Jain, S., et al. (2021). “Bioactive compounds from Murraya koenigii and their cytotoxic effects against cancer cells.” Journal of Cancer Research and Therapeutics, 17(1), 31-36. doi:10.4103/jcrt.JCRT_614_18
5. Raghavendra, R., et al. (2017). “The role of Murraya koenigii in cancer treatment: A systematic review.” World Journal of Clinical Oncology, 8(6), 480-489. doi:10.5306/wjco.v8.i6.480 6. Sahu, P. K., & Khatri, S. (2020). “Murraya koenigii: A review of its medicinal properties and cytotoxic potential.” Current Drug Metabolism, 21(1), 45-53. doi:10.2174/1389201020666200107115847
7. Sharma, R., et al. (2019). “Curry leaf extract: A promising candidate for cancer therapy.” Journal of Medicinal Plants Research, 13(1), 1-9. doi:10.5897/JMPR2018.6582
8. Bharati, K. M., & Shobha, R. (2021). “Murraya koenigii: A potential source for anticancer agents.” Journal of Herbal Medicine and Toxicology, 15(1), 55-60. doi:10.4103/jhmt.jhmt_38_20
9. Gupta, P., et al. (2022). “Phytochemical constituents of Murraya koenigii and their potential in cancer therapy.” Journal of Ethnopharmacology, 284, 114766. doi:10.1016/j.jep.2021.114766
10. Nikhil, K., & Soni, S. (2020). “Exploring the antitumor potential of Murraya koenigii in various cancer models.” Indian Journal of Pharmaceutical Sciences, 82(4), 601-611. doi:10.36468/pharmaceutical-sciences.690
11. Patel, S., & Ghosh, S. (2021). “Anticancer properties of Murraya koenigii: A review of its phytochemistry and pharmacological potential.” Journal of Cancer Research and Therapeutics, 17(3), 533-540. doi:10.4103/jcrt.JCRT_613_20
12. Alkhalaf, M. I., et al. (2020). “Murraya koenigii and its bioactive compounds: Potential anticancer agents.” Pharmacognosy Reviews, 14(28), 72-80. doi:10.4103/pr.pr_32_20
13. Sharma, S., et al. (2022). “Cytotoxic activity of Murraya koenigii against human cancer cell lines: A systematic review.” Toxicology Reports, 9, 925-934. doi:10.1016/j.toxrep.2022.05.008
14. Raghunandan, H., & Karunakar, P. (2021). “Evaluation of Murraya koenigii extracts for their cytotoxic effects on breast cancer cells.” Asian Journal of Pharmaceutical and Clinical Research, 14(1), 122-127. doi:10.22159/ajpcr.2021.v14i1.39652
15. Ranjan, A., et al. (2023). “The anticancer potential of Murraya koenigii: A molecular perspective.” Journal of Medicinal Food, 26(2), 123-135. doi:10.1089/jmf.2022.01342
16. Bhanja, S., et al. (2022). “Murraya koenigii: An overview of its phytochemistry and anticancer potential.” International Journal of Pharmaceutical Sciences and Research, 13(4), 1572-1581. doi:10.13040/IJPSR.0975-8232.13(4).1572-81
17. Srinivasan, M., & Suresh, S. (2021). “Cytotoxicity of Murraya koenigii extracts on human cancer cell lines.” Journal of Cancer Science & Therapy, 13(3), 305-311. doi:10.4172/1948-5956.1000790
18. Kumar, P., et al. (2020). “The role of Murraya koenigii in cancer management: A review.” Phytotherapy Research, 34(8), 1801-1811. doi:10.1002/ptr.6732
19. Mishra, A., & Mohanty, S. (2023). “Antitumor activity of Murraya koenigii: Evidence from preclinical studies.” BMC Complementary Medicine and Therapies, 23(1), 112. doi:10.1186/s12906-023-02280-0
20. Vishwakarma, R., et al. (2022). “Cytotoxic evaluation of Murraya koenigii against various cancer cell lines.” Journal of Ethnopharmacology, 283, 114668. doi:10.1016/j.jep.2021.11466821.Choudhary, A., et al. (2022). “Phytochemical constituents and cytotoxicity of Murraya koenigii: A review.” Asian Journal of Pharmaceutical and Clinical Research, 15(5), 50-58. Doi:10.22159/ajpcr.2022.v15i5.45549
22. Panda, S., et al. (2021). “Murraya koenigii: A potential source of bioactive compounds for cancer therapy.” Journal of Herbal Medicine, 27, 100426. Doi:10.1016/j.hermed.2021.100426
23. Singh, K., & Singh, R. (2023). “Evaluating the cytotoxic potential of Murraya koenigii extracts on various cancer cell lines.” Journal of Medicinal Chemistry, 66(3), 1567-1581. Doi:10.1021/acs.jmedchem.2c00723
24. Thakur, M., et al. (2020). “The antitumor efficacy of Murraya koenigii: Insights into its mechanism of action.” Pharmacognosy Magazine, 16(67), 505-514. Doi:10.4103/pm.pm_44_20
25. Kaur, P., et al. (2023). “Murraya koenigii as a therapeutic agent: Its role in cancer treatment.” Journal of Cancer Research, 29(4), 304-315. Doi:10.1016/j.jcr.2023.05.003
26.Reisch J, Goj O, Wickramasinghe A, Bandara Herath HMT, Henkel G. Carbazole alkaloids from seeds of Murraya koenigii. Phytochemistry. 1992;31(8):2877–9. Available from: https://www.Sciencedirect.com. /science/article/pii/003194229283651E
27. Tachibana Y, Kikuzaki H, Lajis NH, Nakatani N. Comparison of antioxidative properties of carbazole alkaloids from Murraya Koenigii leaves. J Agric Food Chem. 2003;51(22):6461–
28.Nakamura S, Nakashima S, Oda Y, Yokota N, Fujimoto K, Matsumoto T, et al. Alkaloids from Sri Lankan curry-leaf (Murraya Koenigii) display melanogenesis inhibitory activity: structures of Karapinchamines A and B. Bioorg Medi Chem. 2013;21(5):1043–9. Doi: http://dx.doi.org/10.1016/j.bmc.2013.01.012
29. Bakar NHA, Khalid K, Sukari MA, Yusuf UK. Chemical constituents From stem barks and roots of Murraya koenigii (Rutaceae). Malays J Anal Sci. 2007;11(1):173–6.
30.Tan SP, Nafiah MA, Ahmad K. C23-carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng. J Chem Pharm Res. 2014;6(4):1093–8.