Volume : 12, Issue : 03, March – 2025
Title:
FORMULATION AND CHARACTERIZATION OF ENALAPRIL MICROPARTICLES USING GRAFT COPOLYMERIZED HYDROGEL
Authors :
Afshan Sultana, Sumer Singh, Niranjan Panda, M.S.Ansari
Abstract :
The aim of the present study was to formulate and evaluate Enalapril Microparticles through graft copolymerization procedures, utilizing guar gum as the natural polymer and polyacrylamide as the synthetic polymer. The optimal hydrogel formulation was developed as microparticles, loaded with Enalapril, and evaluated using various parameters. The graft copolymer was characterized using FTIR, DSC, and SEM. The preparation conditions of the beads were adjusted by evaluating the % entrapment efficiency, particle size, swelling capacity under varying pH settings, and their release profiles. FTIR studies support the development of grafted copolymers, whereas DSC tests indicate a relatively enhanced thermal stability of these copolymers. The guar gum-g-poly(acrylamide) and sodium alginate (pAAm-g-GG/SA) microparticles exhibited a nearly spherical morphology, as demonstrated by the SEM analysis. The swelling index was highest in phosphate buffer at pH 6.8 with increased concentrations of sodium alginate and guar gum, and lowest with larger concentrations of ethyl cellulose. Microparticles enalapril was discovered to be regulated with an increase in polyacrylamide and sodium alginate content in the microparticles, with a greater release noted in a pH 6.8 medium compared to pH 1.2. The in vitro release kinetics of Enalapril from the polymeric beads adhered to the Zero-order release with drug release as anomalous diffusion. Microparticles of Enalapril based on hydrogel were effectively synthesized with optimal formulations of pAAm-g-GG/SA by a free radical ionization process. All characterization parameters met the acceptance standards.
Keywords: Hydrogel, Microparticles, Enalapril, Guar gum, Acrylamide, Sodium alginate
Cite This Article:
Please cite this article in press Afshan Sultana et al., Formulation And Characterization Of Enalapril Microparticles Using Graft Copolymerized Hydrogel., Indo Am. J. P. Sci, 2025; 12(03).
Number of Downloads : 10
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