Volume : 12, Issue : 03, March – 2025

Title:

INVESTIGATING THE ROLE OF EPIGENETIC MODIFICATIONS IN MEDIATING DRUG RESISTANCE IN CANCER CELL
‬

Authors :

Gauri karanjkar, Sanika Chandel, Sanika Merkute, Rohan Wakale, Bhagvat Mutkule, Amol Khandare

Abstract :

Cancer drug resistance remains a major barrier to effective treatment and long-term remission, often leading to therapeutic failure and disease relapse. While genetic mutations have traditionally been recognized as key drivers of resistance, recent evidence highlights the crucial role of epigenetic modifications heritable but reversible changes in gene expression that do not involve alterations in the DNA sequence in modulating cancer cell behavior and drug response. This study aims to investigate how key epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, contribute to the development and maintenance of drug resistance in cancer cells. By employing epigenetic profiling techniques, functional assays, and treatment with
Epigenetic modulators such as DNA thioltransferase and histone deacetylase inhibitors, we seek to elucidate the relationship between epigenetic alterations and drug resistance pathways. The findings are expected to provide insights into novel therapeutic strategies to reverse resistance and identify predictive biomarkers, ultimately contributing to the advancement of personalized cancer therapy.
Keywords : Epigenetics, Drug resistance, Cancer cells, DNA methylation, Histone modification, Non-coding RNAs, Epigenetic therapy, Biomarkers

Cite This Article:

Please cite this article in press Gauri karanjkar et al., Investigating The Role Of Epigenetic Modifications In Mediating Drug Resistance In Cancer Cell.,, Indo Am. J. P. Sci, 2025; 12(05).

Number of Downloads : 10

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