Volume : 12, Issue : 03, March – 2025
Title:
DEPRESSION: A REVIEW
Authors :
Shiva Ramkisan Dhande, Ajay R. Zagade, Puja Bekatet, Swati P. Deshmukh
Abstract :
Depression is a prevalent and multifaceted mental health disordercharacterized by persistent sadness, loss of interest in activities, and impaired cognitive and physical functioning. It affects individuals globally, with varying prevalence and symptomatology influenced by cultural and environmental factors. Traditional theories, such as the serotonin hypothesis, have recently been challenged, leading to broader explorations of genetic, neurobiological, environmental, and psychological contributors. Effective diagnosis relies on clinical criteria outlined in frameworks like the DSM-5. Treatment approaches are diverse, including pharmacotherapy (e.g., SSRIs), psychotherapy (e.g., CBT), lifestyle interventions, and alternative therapies like mindfulness and light therapy. Recent developments in research have highlighted the limitations of antidepressants and the need for personalized treatment strategies. This review underscores the complexity of depression and emphasizes the necessity of an integrated approach to its management, incorporating advances in research to improve.
Key words: Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), Serotonin Hypothesis, Genetic Predisposition, Neurobiological Factors, Cognitive Behavioral Therapy (CBT), Pharmacotherapy (SSRIs, SNRIs), Psychotherapy, Mindfulness Meditation,Light Therapy,Lifestyle Interventions,Exercise and Mental Health,Suicidal Ideation,Diagnosis (DSM-5 Criteria),Emotional Numbing,Risk Factors (Environmental, sychological),Antidepressant Efficact, Comorbidities (Anxiety, Bipolar Disorder),Neuroplasticity and Depression
Cite This Article:
Please cite this article in press Shiva Ramkisan Dhande et al., Depression: A Review., Indo Am. J. P. Sci, 2025; 12(05)..
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References:
1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
2. Cuijpers, P., Karyotaki, E., Weitz, E., Andersson, G., van Straten, A. (2016). The effects of psychotherapies for major depression in adults on remission: A meta-analysis. Journal of Affective Disorders,
3. Fava, G. A., & Tomba, E. (2009). The concept of recovery in major depression. Psychological Medicine, 39(2), 307-313.
4. Gorman, C. L., & Gomez, J. L. (2014). The role of serotonin and its dysfunction in depression. Journal of Clinical Psychiatry, 75(4), 38-48
5. Hofmann, S. G., Asnaani, A., Vonk, I. J., Sawyer, A. T., & Fang, A. (2012). The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analyses. Cognitive Therapy and Research, 36(5),
6. Holzel, B. K., Carmody, J., Vangel, M., Congleton, C., Yerramsetti, S. M., & Cook, R. (2011). Mindfulness meditation training alters brain structure in participants with major depressive disorder. Psychiatry Research
7. Ng, F., & Sim, K. (2017). A review of antidepressant efficacy in major depressive disorder. Clinical Psychopharmacology and Neuroscience
8. National Institute of Mental Health. (2021). Depression.
9. Rethorst, C. D., Wipfli, B. M., & Landers, D. M. (2009). The antidepressive effects of exercise: A meta-analysis of randomized trials. Sports Medicine,
10. St John’s Wort for Depression Study Group. (2002). Efficacy of St. John’s Wort in major depressive disorder: A meta-analysis of randomized controlled trials. JAMA,
11. Thase, M. E., & Rush, A. J. (2009). When at first you don’t succeed: Sequential strategies for antidepressant nonresponders. Journal of Clinical Psychiatry
12. Bauer, M., & Pfennig, A. (2005). Early intervention in depression: A critical review of treatment strategies. European Archives of Psychiatry and Clinical Neuroscience, 255(5), 342-349.
13. Beck, A. T., & Dozois, D. J. A. (2011). Cognitive therapy: Current status and future directions. Annual Review of Medicine,
14. Cipriani, A., et al. (2016). Comparative efficacy and acceptability of antidepressants in the treatment of major depressive disorder in adults: A systematic review and network meta-analysis.
15. Cuijpers, P., & Andersson, G. (2012). Internet-delivered psychological treatments for depression: A meta-analytic review. Journal of Affective Disorders, 140(1), 26-37.
16. Friedrich, M. J. (2017). Depression is the leading cause of disability around the world.
17. Kroenke, K., et al. (2001). The PHQ-9: Validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606-613
18. Parker, G., & Gladstone, G. (2010). What is depression? Australian and New Zealand Journal of Psychiatry,
19. Sarris, J., et al. (2012). Herbal medicine in the treatment of depression: A systematic review of efficacy, safety and pharmacological mechanisms. Journal of Affective Disorders, 147(3), 214- 222.
20. Sharma, T., & Chawla, S. (2019). Pharmacological treatment of depression: A review of current and emerging therapies. Indian Journal of Psychiatry, 61(6), 98-105
21. Sweeney, R., & Watson, P. (2003). A randomized controlled trial of exercise for depression in primary care. Journal of Psychosomatic Research, 54(1),
22. Thase, M. E., & Joffe, R. T. (2001). The management of treatment-resistant depression. Journal of Clinical Psychiatry, 62.