Volume : 12, Issue : 03, March – 2025
Title:
COMPARISON OF HEPATIC AND EXTRAHEPATIC SCORES IN PREDICTING MORTALITY IN HEPATITIS C-RELATED CIRRHOSIS: A SINGLE CENTRE STUDY AT GUJRANWALA MEDICAL COLLEGE
Authors :
Muhammad Ali Raza, Abdul Moeed Baig, Dr Sara Saleem
Abstract :
Background: Hepatitis C virus (HCV) remains a leading cause of cirrhosis and liver-related mortality worldwide. Accurate prediction of mortality is essential for risk stratification and management. Both hepatic and extrahepatic scoring systems have been proposed.
Objective: To compare the efficacy of hepatic (Child-Pugh, MELD) and extrahepatic (CLIF-C, SOFA) scores in predicting mortality among patients with HCV-related cirrhosis.
Methods: This prospective study was conducted at Gujranwala Medical College, Pakistan. Patients with confirmed HCV-related cirrhosis were enrolled and followed for 90-day mortality outcomes. Scores were calculated on admission, and their predictive performances were compared using AUROC analyses.
Results: A total of 150 patients were included. The AUROC for CLIF-C ACLF was 0.88, for SOFA 0.85, for MELD 0.78, and for Child-Pugh 0.75. Extrahepatic scores outperformed traditional hepatic scores in mortality prediction.
Conclusion: Extrahepatic scores like CLIF-C and SOFA showed superior mortality prediction compared to hepatic scores in HCV-cirrhosis.
Keywords: Hepatitis C, Cirrhosis, Mortality Prediction, MELD, Child-Pugh, CLIF-C, SOFA
Cite This Article:
Please cite this article in press Muhammad Ali Raza et al., Comparison Of Hepatic And Extrahepatic Scores In Predicting Mortality In Hepatitis C-Related Cirrhosis: A Single Centre Study At Gujranwala Medical College., Indo Am. J. P. Sci, 2025; 12(05).
Number of Downloads : 10
References:
1. World Health Organization. Global hepatitis report 2024. WHO; 2024.
2. Abbas M, Butt ZA. Prevalence and Risk Factors of Hepatitis C in Pakistan. Int J Infect Dis. 2024;141:47-53.
3. Tapper EB, Lok ASF. Use of the MELD score to predict mortality in cirrhosis. Curr Opin Gastroenterol. 2024;40(2):123–128.
4. Pugh RN et al. Prognostic value of Child-Pugh classification in cirrhosis. Liver Int. 2023;43(5):1105-1112.
5. Jalan R et al. Systemic inflammation and organ failure in cirrhosis. Hepatology. 2023;77(2):565-576.
6. Gustot T, Moreau R. CLIF-C ACLF score: development and validation. Hepatology. 2023;78(1):250-262.
7. Artru F et al. SOFA score as a tool for risk stratification in cirrhotic patients. Crit Care Med. 2024;52(3):413-420.
8. Drolz A et al. Organ dysfunction and prognosis in cirrhosis. Hepatology. 2024;79(4):1501-1512.
9. Weiss E, Jochum C. Extrahepatic organ failure in liver disease. Clin Liver Dis. 2023;27(1):87-104.
10. Irfan M et al. Mortality predictors in cirrhosis: A Pakistani cohort. Pak J Med Sci. 2024;40(2):245-252.
11. Bernal W et al. Multi-organ failure in acute-on-chronic liver failure. Nat Rev Gastroenterol Hepatol. 2024;21(2):85-97.
12. Piano S, Tonon M. Organ dysfunction and prognosis in liver cirrhosis. J Hepatol. 2023;78(2):328-339.
13. Trebicka J et al. The impact of systemic inflammation in liver cirrhosis. Gut. 2023;72(4):669-681.
14. Kim WR et al. MELD score and beyond: assessing liver disease severity. Hepatol Commun. 2024;8(1):20-32.
15. Biggins SW et al. Review of scoring systems in end-stage liver disease. Liver Transpl. 2023;29(3):328-341.
16. Fernández J, et al. Extrahepatic organ failure and outcome prediction in ICU cirrhotics. Ann Intensive Care. 2024;14(1):22.
17. Nasir U et al. Cirrhosis and acute-on-chronic liver failure in South Asia. JGH Open. 2024;8(1):92-99.
18. Butt AS, Sharif F. Hepatitis C burden in Pakistan: recent updates. Hepatol Int. 2024;18(2):321-329.
19. Khan RS et al. HCV epidemiology and future projections in Pakistan. Liver Int. 2024;44(1):15-22.