Volume : 12, Issue : 03, March – 2025
Title:
COMPARATIVE ANALYSIS OF CRUDE FIBER AND LAXATIVE POTENTIAL OF FIVE DRY FRUITS IN LOPERAMIDE-INDUCED CONSTIPATION IN ALBINO RATS
Authors :
D. Veerendra Kumar* ,Rongala Durgaprasad, Teegireddy Pardhava Sandeep , Pyla Satya Sai Ramesh , Routhu Praveen Kumar , Ummadi Naga Chandu , Devanaboyina Narendra
Abstract :
The primary aim of the study is to treat constipation by evaluating the crude fiber content and laxative activity of selected dry fruits—Prunus dulcis (almond), Juglans regia (walnut), Vitis vinifera (raisins), Phoenix dactylifera (date palm), and Anacardium occidentale (cashew nut)—through in vitro and in vivo studies using albino rats. Constipation, a condition marked by difficulty in bowel movement and hardened stools, can be alleviated through dietary fiber, which consists of indigestible polysaccharides and lignin.
The crude fiber content of these dry fruits was measured using the Maynard method (1970), and their laxative effects were assessed using the Capasso method in rats. Constipation was induced using the drug loperamide, and the effectiveness of the dry fruits was observed. The results showed the highest crude fiber content in walnuts (65%), followed by almonds (42.6%), date palms (19.8%), cashews (13.42%), and raisins (0.8%). The corresponding order of laxative activity was walnuts (80.5%) > almonds (67%) > date palms (43.61%) > cashews (38.79%) > raisins (31.56%).
The study concludes that walnuts exhibited the most effective laxative activity and may serve as a natural remedy for constipation.
Keywords: Constipation, crude fiber, laxative activity, Prunus dulcis, Juglans regia, Vitis vinifera, Phoenix dactylifera, Anacardium occidentale.
Cite This Article:
Please cite this article in press D. Veerendra Kumar et al., Comparative Analysis Of Crude Fiber And Laxative Potential Of Five Dry Fruits In Loperamide-Induced Constipation In Albino Rats., Indo Am. J. P. Sci, 2025; 12(05).
Number of Downloads : 10
References:
1. &NA; (2010). Castor oil. Reactions Weekly, NA;(1332), 14. https://doi.org/10.2165/00128415-201013320-00042
2. 1, A. O.-C. D. E.-A., Pérez, A. J., Marhuenda-Muñoz, M., Lamuela-Raventós, R. M., & Vallverdú-Queralt, A. (2020). The Facts on Raisins & Dried Fruits. Nutrients, 12(1), 1–17.
3. Andromanakos, N., Skandalakis, P., Troupis, T., & Filippou, D. (2006). Constipation of anorectal outlet obstruction: Pathophysiology, evaluation and management. Journal of Gastroenterology and Hepatology (Australia), 21(4), 638–646. https://doi.org/10.1111/j.1440-1746.2006.04333.x
4. Av, S., Di, L., An, L., Nv, B., Nv, K., & Rm, K. (2019). Study of Outward Signs, Microscopy and Chemical Composition of Walnut. Asian Journal of Pharmaceutical and Clinical Research, 12(1), 173. https://doi.org/10.22159/ajpcr.2018.v12i1.28197
5. Basilisco, G., & Coletta, M. (2013). Chronic constipation: A critical review. Digestive and Liver Disease, 45(11), 886–893. https://doi.org/10.1016/j.dld.2013.03.016
6. Boriss, H., Brunke, H., & Kreith, M. (2006). Commodity Profile: English Walnuts. Center, Agricultural Issues, March, 1–8.
7. Bowel Function Anatomy. (2008). 1–3.
8. Busuttil-Griffin, F., Shoemake, C., Attard, E., & Azzopardi, L. M. (2015). Crude Fibre Determination of Malva sylvestris L. and Evaluation of its Faecal Bulking and Laxative Properties in Rats. International Journal of Biology, 7(4). https://doi.org/10.5539/ijb.v7n4p1
9. Chamundeeswari, D., Kanimozhi, P., & Reddy, C. U. (2007). Formulation and Evaluation of Churna for Digestive Property. Journal of Medicine, 1–5.
10. Chemical Composition and Formation of Human Feces – Problems and Solutions of Large Mergers Demographics in. (n.d.). 2012, 2012.
11. Coleman, R. L., Hennessy, B. T., Coleman, R. L., & Markman, M. (2015). Ovarian cancer Ovarian cancer. Critical Reviews in Oncology/Hematology, 6736(June), 433–440. https://www.sciencedirect.com/science/article/abs/pii/S1040842806000643?via%3Dihub
12. Cosmulescu, S., Trandafir, I., Achim, G., Botu, M., Baciu, A., & Gruia, M. (2010). Phenolics of green husk in mature walnut fruits. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 38(1), 53–56. https://doi.org/10.15835/nbha3814624
13. Dai, F. J., & Chau, C. F. (2017). Classification and regulatory perspectives of dietary fiber. Journal of Food and Drug Analysis, 25(1), 37–42. https://doi.org/10.1016/j.jfda.2016.09.006
14. Dhingra, D., Michael, M., Rajput, H., & Patil, R. T. (2012). Dietary fibre in foods: A review. Journal of Food Science and Technology, 49(3), 255–266. https://doi.org/10.1007/s13197-011-0365-5
15. Dreyer, J. J. (1969). The biological assessment of protein quality: effects of consumption of “crude fibre”, NaCl and body hair on faecal nitrogen excretion in the rat. South African Medical Journal, 43(25), 776–786.
16. Fiber. (n.d.).
17. Jha, R., & Mishra, P. (2021). Dietary fiber in poultry nutrition and their effects on nutrient utilization, performance, gut health, and on the environment: a review. Journal of Animal Science and Biotechnology, 12(1), 1–16. https://doi.org/10.1186/s40104-021-00576-0
18. Keenan, M. J., Zhou, J., Hegsted, M., Pelkman, C., Durham, H. A., Coulon, D. B., & Martin, R. J. (2015). Role of resistant starch in improving gut health, adiposity, and insulin resistance. Advances in Nutrition, 6(2), 198–205. https://doi.org/10.3945/an.114.007419
19. Khiari, R., Zemni, H., & Mihoubi, D. (2019). Raisin processing: physicochemical, nutritional and microbiological quality characteristics as affected by drying process. Food Reviews International, 35(3), 246–298. https://doi.org/10.1080/87559129.2018.1517264
20. Krueger, R. R. (2012). Date Palm Genetic Resource Conservation , Breeding , Genetics , And Genomics In California Date Palm Germplasm In California.
21. Li, Y., Tong, W. D., & Qian, Y. (2021). Erratum: Effect of physical activity on the association between dietary fiber and constipation: Evidence from the National health and nutrition examination survey 2005-2010 (J Neurogastroenterol Motil (2021) 27:1 (97-109) DOI: 10.5056/jnm20051). Journal of Neurogastroenterology and Motility, 27(3), 440. https://doi.org/10.5056/JNM20051E
22. Madhu, C., Krishna, K. M., Reddy, K. R., Lakshmi, P. J., & Kelari, E. kumar. (2017). Estimation of Crude Fibre Content from Natural Food Stuffs and its Laxative Activity Induced in Rats. International Journal of Pharma Research and Health Sciences, 5(3), 1703–1706. https://doi.org/10.21276/ijprhs.2017.03.04
23. Maffei, H. V. L. (2004). Author’s reply [2]. Jornal de Pediatria, 80(6), 527–530. https://doi.org/10.2223/JPED.1269
24. Mayo Clinic Staff. (2012). Dietary fiber: Essential for a healthy diet. MayoClinic.Org. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/fiber/art-20043983%0Ahttp://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/fiber/art-20043983?pg=1
25. Palit, S., Lunniss, P. J., & Scott, S. M. (2012). The physiology of human defecation. Digestive Diseases and Sciences, 57(6), 1445–1464. https://doi.org/10.1007/s10620-012-2071-1
26. Patel, V. R., Dumancas, G. G., Viswanath, L. C. K., Maples, R., & Subong, B. J. J. (2016). Castor oil: Properties, uses, and optimization of processing parameters in commercial production. Lipid Insights, 9(1), 1–12. https://doi.org/10.4137/LPI.S40233
27. Rao, S. S. C., & Go, J. T. (2010). Update on the management of constipation in the elderly: new treatment options. Clinical Interventions in Aging, 5, 163–171. https://doi.org/10.2147/cia.s8100
28. Yadilal, G., Manisha, M., Pavani, E., Navya, M., Alekhya, C., Chandini, G. H., & Madhu, C. (2017). FRUITS. 4(10), 3864–3868.
29. Yang, J., Wang, H. P., Zhou, L., & Xu, C. F. (2012). Effect of dietary fiber on constipation: A meta analysis. World Journal of Gastroenterology, 18(48), 7378–7383. https://doi.org/10.3748/wjg.v18.i48.7378
30. Yang, Y. Y., Ma, S., Wang, X. X., & Zheng, X. L. (2017). Modification and Application of Dietary Fiber in Foods. Journal of Chemistry, 2017. https://doi.org/10.1155/2017/9340427
31. Yangilar, F. (2013). The Application of Dietary Fibre in Food Industry : Structural Features , Effects on Health and Definition , Obtaining and Analysis of Dietary Fibre : A Review. 1(3), 13–23. https://doi.org/10.12691/jfnr-1-3-1.