Volume : 12, Issue : 03, March – 2025
Title:
CURCUMIN-LOADED SOLID LIPID NANOPARTICLES: A NOVEL APPROACH FOR IMPROVING ANTI-DIABETIC ACTIVITY AND BIOAVAILABILITY
Authors :
Jade Shankar*, Dr, G Gopi , Dr, P.K Prakash Reddy
Abstract :
Background: Curcumin is effective in the treatment of diabetes mellitus. But they have low aqueous solubility and poor bioavailability. Solid lipid nanoparticles (SLN) could be used to enhance their effectiveness as they increase the bioavailability of lipophilic compounds and protect the drug from gastrointestinal degradation. The main objective of the present study was to prepare solid lipid nanoparticles of curcumin to improve their pharmacokinetics and antidiabetic activities in streptozotocin induced-diabetic rats.
Results & Discussion: The actual values of the particle size, %EE, and PDI were found to be in close agreement with the predicted values obtained for the optimized Cur-SLN. TEM results confirmed the monodispersion and spherical shape of the particles and DSC results confirmed the change of drug from crystalline to amorphous form in the optimized Cur-SLN. The formulations showed burst release of the drug followed by sustained release. The results of pharmacokinetic study showed the enhancement of bioavailability in the optimized formulations of curcumin than compared to the plain drug suspension. The improvement in the body weight with a marked reduction in the fasting blood glucose level was observed for optimized Cur- SLN than compared to their plain drug suspension.
Conclusion: Curcumin loaded SLN were successfully prepared and showed remarkable effectiveness in the management of diabetes mellitus.
Key words: Curcumin, solid lipid nanoparticles , pharmacokinetics ,diabetes mellitus.
Cite This Article:
Please cite this article in press Jade Shankar et al., Curcumin-Loaded Solid Lipid Nanoparticles: A Novel Approach For Improving Anti-Diabetic Activity And Bioavailability., Indo Am. J. P. Sci, 2025; 12(05).
Number of Downloads : 10
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