29.Issue 05 may 25 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 12, Issue : 03, March – 2025

Title:

DESIGN, DEVELOPMENT AND CHARACTERIZATION OF MEDICATED JELLIES BY USING DIFFERENT GUMS

Authors :

Rehan M. Beniwale*, Dr. Amol A. Harsulkar, Aniket V. kadam, Akshay B. Jadhav

Abstract :

The current study focused on the formulation, optimization, and evaluation of a novel medicated jelly containing Cephalexin and Flurbiprofen to enhance patient compliance and ensure effective, stable drug delivery. Pre-formulation studies confirmed the identity, purity, and compatibility of the active pharmaceutical ingredients (APIs) with selected excipients. Cephalexin showed favorable solubility across various solvents, while Flurbiprofen’s limited solubility highlighted the need for formulation adjustments. FTIR and DSC analyses confirmed no significant drug-excipient interactions and supported thermal stability. Thirteen jelly formulations were developed using various concentrations of gelling agents and pH adjusters. Among these, formulation F5 demonstrated optimal physicochemical properties, including a uniform glossy appearance, desirable pH (6.0), excellent viscosity (6140 cP), and high drug content uniformity (99%). In-vitro release studies revealed that F5 achieved a cumulative release of 98% within 60 minutes. Stability studies over 60 days indicated consistent performance with minimal changes in drug content and physical characteristics. The results suggest that F5 is a stable, effective, and patient-friendly dosage form, making it a promising candidate for delivering combined antibiotic and anti-inflammatory therapy.
Keywords: Medicated Jelly, Cephalexin, Flurbiprofen, Oral Drug Delivery, Drug Release, Stability Studies.

Cite This Article:

Please cite this article in press Rehan M. Beniwale et al., Design, Development And Characterization Of Medicated Jellies By Using Different Gums., Indo Am. J. P. Sci, 2025; 12(05).

Number of Downloads : 10

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