Volume : 12, Issue : 03, March – 2025

Title:

FORMULATION AND EVALUATION OF POLYHERBAL ANTIDIABETIC TABLET

Authors :

Sakshi.A.Waybht , Priyanka.R.Nagargoje , Dr. Kumar P.Surwase

Abstract :

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Despite the availability of various synthetic antidiabetic agents, their long-term use often leads to adverse effects such as hypoglycemia, weight gain, and organ toxicity. In recent years, herbal medicines have gained attention due to their safety, affordability, and holistic approach. The present study focuses on the formulation and evaluation of a polyherbal antidiabetic tablet composed of five medicinally important plant-based ingredients: Jamun seed (Syzygium cumini), Neem leaf (Azadirachta indica), Tulsi leaf (Ocimum sanctum), Karela fruit (Momordica charantia), and Honey. These herbs are traditionally known for their potent antihyperglycemic, antioxidant, and pancreatic β-cell regenerative activities.The tablets were formulated using the wet granulation method and evaluated for various physicochemical parameters such as hardness, friability, weight variation, disintegration time, and drug content uniformity. In vitro antidiabetic activity was assessed using alpha-amylase and alpha-glucosidase inhibition assays. The results indicated that the prepared tablets met all pharmacopoeial standards and showed promising antidiabetic activity, comparable to standard drugs. The study concludes that polyherbal formulations can be an effective and natural alternative for diabetes management, supporting the integration of traditional knowledge with modern pharmaceutical practices.

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