Volume : 12, Issue : 11, November – 2025

Title:

A REVIEW ON NANOROBOT IN CANCER TREATMENT

Authors :

Vaishnavi Devidas Jaybhaye, Sakshi Suryakant Tipale, Shubham Santosh Shinde, Mr. Swapnil P. Kulthe.

Abstract :

Early detection and diagnosis of many cancers is very challenging. Late stage detection of a cancer always leads to high mortality rates. It is imperative to develop novel and more sensitive and efective diagnosis and therapeutic methods for cancer treatments. The development of new cancer treatments has become a crucial aspect of medical advancements. Nanobots, as one of the most promising applications of nanomedicines, are at the forefront of multidisciplinary research. With the progress of nanotechnology, nanobots enable the assembly and deployment of functional molecular/nanosized machines and are increasingly being utilized in cancer diagnosis and therapeutic treatment. In recent years, various practical applications of nanobots for cancer treatments have transitioned from theory to practice, from in vitro experiments to in vivo applications. In this paper, we review and analyze the recent advancements of nanobots in cancer treatments, with a particular emphasis on their key fundamental features and their applications in drug delivery, tumor sensing and diagnosis, targeted therapy, minimally invasive surgery, and other comprehensive treatments. At the same time, we discuss the challenges and the potential research opportunities for nanobots in revolutionizing cancer treatments. In the future, medical nanobots are expected to become more sophisticated and capable of performing multiple medical functions and tasks, ultimately becoming true nanosubmarines in the bloodstream.
Key-words:- Nanorobots, Cancer treatment, Drug delivery, Targeted therapy.

Cite This Article:

Please cite this article in press Vaishnavi Devidas Jaybhaye et al., A Review On Nanorobot In Cancer Treatment, Indo Am. J. P. Sci, 2025; 12(11).

REFERENCES:

1] U.S. Department of Health and Human ServicesNational Institutes of HealthNational Cancer InstituteUSA.gov.
2] Debjit B, Chiranjib, Margret chandira R, Jayakaret B. Role of nanotechnology in novel
drug delivery system. J Pharm Sci and Tech, 2009; 1: 20-35.
3] Cerofolini, G., Amato, P., Masserini, M., Mauri, G. “A Surveillance System for EarlyStage Diagnosis of Endogenous Diseases by Swarms of Nanobots”. Advanced Science
Letters 2010;3:4: 345–352.
4] Freitas Jr, R.A., 2005. What is nanomedicine? Nanomed. Nanotech. Biol. Med. 1, 2–9.
5] J. Wang, Nanomachines: Fundamentals and Applications, John Wiley & Sons, 20135.
6] S.M. Douglas, I. Bachelet, G.M. Church, A Logic-Gated Nanorobot for Targeted Transport
of Molecular Payloads, Science 335 (2012) 831–834.
7] M.P. Nikitin, V.O. Shipunova, S.M. Deyev, P.I. Nikitin, Biocomputing based on particle
disassembly, Nat. Nanotechnol. 9 (2014) 716–722.
8] Y. Amir, E. Ben-Ishay, D. Levner, S. Ittah, A. Abu-Horowitz, I. Bachelet, Universal
computing by DNA origami robots in a living animal, Nat. Nanotechnol. 9 (2014) 353–
357.
9] R. Freitas, Journal of Computational and Theoretical Nanoscience, 2005 Vol.2, pp. 1–25.
10] Yarin A. L. Urbanke, C., Manstein “Nanofibers, nanofluidics, nanoparticles and nanobots
for drug and protein delivery systems”. Scientia Pharmaceutica Central European Symposium on Pharmaceutical Technology 2010;78:3:542.
11] A.A.G. Requicha, Nanorobots, NEMS and Nanoassembly. Proceedings of theIEEE,2003,
9, 1922-1926.
12] Journal of Molecular Liquids Volume 348, 15 February 2022, 118008 https://doi.org/10.1016/j.molliq.2021.118008 A review on nanotechnology: Properties, applications, and mechanistic insights of cellular uptake mechanisms.
13] Vogel H.G., Maas J., Gebauer A. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Springer; Berlin/Heidelberg, Germany: 2020. Nanotechnology in medicine; pp. 533–546.
14] 2023 Jan 9;28(2):661. doi: 10.3390/molecules28020661 Nanotechnology: A Revolution in Modern Industry national Library of Medicine.PMC PubMed Central.
15] Rahul, V.A. A brief review on nanorobots. SSRG-IJME 2017, 4, 15–21. [Google Scholar] [CrossRef] [Green Version].
16] Neto, A.; Lopes, I.A.; Pirota, K. A Review on Nanorobotics. J. Comput. Theor. Nanosci. 2010, 7, 1870–1877. [Google Scholar] [CrossRef].
17] Appl. Sci. 2021, 11(21), 10385; https://doi.org/10.3390/app112110385Submission received: 8 October 2021 / Revised: 29 October 2021 / Accepted: 3 November 2021 / Published: 5 November 2021 by Gautham Giri A Brief Review on Challenges in Desig and Development of Nanorobots for Medical Applications.
18] Advances of medical nanorobots for future cancer treatments ReviewOpen accessPublished: 14 July 2023 Volume 16, article number 74, (2023) .
19] Ghulam Muhayyudin Chattha aJournal of Drug Delivery Science and Technology. Volume 80, February 2023, 104173 Review article Nanorobots: An innovative approach for DNA-based cancer treatment.
20] © 2024 American Cancer Society, Inc. All rights reserved. The American Cancer Society is a qualified 501(c)(3) tax-exempt organization. Tax ID Number: 13-1788491.
21] Genes Dis. 2020 Sep 18;8(5):655–661. doi: 10.1016/j.gendis.2020.09.002Cancer: An unknown territory; rethinking before going ahead Arun Upadhyay 1Department of Biochemistry, Central University of Rajasthan, Rajasthan, 305817, IndiaPMCID: PMC8278524 PMID: 34291136.
22] Journal of Molecular Liquids Volume 348, 15 February 2022, 118008 https://doi.org/10.1016/j.molliq.2021.118008 A review on nanotechnology: Properties, applications, and mechanistic insights of cellular uptake mechanisms.
23] International Journal of Engineering Research & Technology (IJERT) ISSN: 2278-0181 Published by, www.ijert.org NCESC – 2018 Conference Proceedings Design & Development of Nanobots for Cancer Cure Applications in Bio-Medical Engineering Rajesh J. 8 th Sem UG BE Student ECE Department, DSCE.
24] Sanchez S, Pumera M. Nanorobots: the ultimate wireless self-propelled sensing and actuating devices. Chem Asian J. 2009;4:1402–10.
25] Hullmann A. Who is winning the global nanorace? Nat Nanotechnol. 2006;1:81–3.
26] van den Heuvel MG, Dekker C. Motor proteins at work for nanotechnology. Science. 2007;317:333–6.
27] Marshall E. Gene therapy death prompts review of adenovirus vector.Science. 1999;286:2244–5.
28] Douglas SM, Bachelet I, Church GM. A logic-gated nanorobot for targeted transport of molecular payloads. Science. 2012;335:831–4.
29] Fan S, Wang D, Kenaan A, Cheng J, Cui D, Song J. Create nanoscale patterns with DNA origami. Small. 2019;15:e1805554.
30] Su CY, Lyu Q, Kang DY, Yang ZH, Lam CH, Chen YH, et al. Hexagonal superalignment of nano-objects with tunable separation in a dilute and spacer-free solution. Phys Rev Lett. 2019;123: 238002.
31] Ning H, Zhang Y, Zhu H, Ingham A, Huang G, Mei Y, et al. Geometry design, principles and assembly of micromotors. Micromachines (Basel). 2018;9:75.
32] Wang, J., Hartmann, F. K., Fedorov R.”Can Man-Made Nanomachines Compete with
Nature Biomotors”. ACS Nano 2011;3(1): 4–9.
33] Rang, H. P., Ritter, J. M., Flower, R. J. and Henderson, G. 2015. Rang & Dale’s
Pharmacology 8th Editio. Churchill Livingstone, 776.
34] Golan, D. E., Tashjian Jr., A. H., Armstrong, E. J. and Armstrong, A. W. 2011. Principles
of Pharmacology: The Pathophysiologic Basis of Drug Therapy. LWW; 3rd edition (June
24, 2011), 976.
35] Brasil Acessed 2015, Publicadas novas normas para pesquisa clínica., Agência Nacional de Vigilância Sanitária-Anvisa. Accessed May 24, 2016.
36] Kratz, F. and Warnecke, A. 2012. “Finding the Optimal Balance: Challenges of Improving
Conventional Cancer Chemotherapy Using Suitable Combinations with Nano-Sized Drug
Delivery Systems.” J Control Release 164: 221-35.
37] Watanabe, K., Nishio, Y., Makiura, R., Nakahira, A. and Kojima, C. 2013. “Paclitaxel-
Loaded Hydroxyapatite/Collagen Hybrid Gels as Drug Delivery Systems for Metastatic Cancer Cells.” International Journal of Pharmaceutics 446 (1-2): 81-6.
38] Garcia-Lopez, V., Chen, F., Nilewski, L.G., Duret, G., Aliyan, A., Kolomeisky, A.B., et al., 2017. Molecular machines open cell membranes. Nature 548, 567-572.
39] Nano RNA Delivery. MIT Technology Review. Available at:
https://www.technologyreview.com/s/410047/nano-rna-delivery/. Accessed 10 October 2017.
40] Vartholomeos, P., Fruchard, M., Ferreira, A., Mavroidis, C., 2011. MRI-guided nanorobotic systems for therapeutic and diagnostic applications. Annu. Rev. Biomed. Eng. 13 (1), 157-184.
41] Shishir Rajendran1 [ Submitted: September 29, 2023 Accepted: January 5,2024 Published: January 11, 2024 ] Nanorobotics in Medicine: A Systematic Review of Advances, Challenges, and Future Prospects with a Focus on Cell Therapy, Invasive Surgery, and Drug Delivery.