Volume : 12, Issue : 11, November – 2025

Title:

FORMULATION DESIGN AND IN VITRO EVALUATION OF TROPISETRON SUSTAINED RELEASE MATRIX TABLETS

Authors :

Arshiya Begum, Lubna Nousheen*, Ayesha Farhath Fathima, Sameena Begum, Sameera Fatima

Abstract :

Tropisetron is taken orally twice daily at a dosage of 5 mg, with a plasma half-life of 20 minutes. The optimal formulation of Tropisetron was determined to be a once-daily sustained-release pill to reduce administration frequency and enhance patient adherence. Using hydrophilic synthetic polymers like hydroxyl propyl methyl cellulose (HPMC K4M & HPMC K15M) and hydrophobic synthetic polymers like Eudragit RSPO and RLPO, the current work sought to evaluate and improve sustained-release Tropisetron matrix tablets. Utilizing a USP type-II paddle type eight station dissolving device, an in vitro release investigation was carried out. The formulation TRS12, consisting of HPMC K15M and Eudragit RSPO grades, was deemed the superior among all formulations. The TRS12 formulation was found to release the drug for up to 12 hours at a steady, regulated rate. To confirm the drug’s compatibility with polymers, FTIR and DSC studies were conducted. Different pre- and post-compression characterizations of the tablet were conducted, and the results complied with pharmacopoeia requirements. Accelerated stability experiments were done to confirm the stability of the dosage formulations.
Key Words: Tropisetron, Sustained-release, HPMC K4M, HPMC K15M, Eudragit RSPO, Eudragit RLPO

Cite This Article:

Please cite this article in press Lubna Nousheen et al., Formulation Design And In Vitro Evaluation Of Tropisetron Sustained Release Matrix Tablets, Indo Am. J. P. Sci, 2025; 12(11).

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