Volume : 12, Issue : 11, November – 2025
Title:
A REVIEW ARTICLE ON POLYHERBAL MOUTHWASH TO APTHOUR ULCER
Authors :
Maviya Choudhari*, Sarika Prakash Chavan, Sapna Ghuge, Dr. Kavita kulkarni
Abstract :
Recurrent aphthous stomatitis (RAS), commonly known as aphthous ulcer or canker sores, causes pain and discomfort for millions worldwide. Conventional therapies such as topical corticosteroids and antiseptic mouthwashes provide relief but may have side effects or limited long-term use. Polyherbal mouthwashes—formulations that combine multiple plant extracts—offer a promising alternative by using synergistic antimicrobial, anti-inflammatory, analgesic, and wound-healing properties of herbs. This review summarizes the biology of aphthous ulcers, rationale for polyherbal therapy, commonly used herbs, formulation considerations, clinical evidence, safety concerns, and future directions. The review highlights clinical trials and systematic findings supporting herbs such as Aloe vera, chamomile, myrrh, licorice (Glycyrrhiza glabra), turmeric (Curcuma longa), and others in oral ulcer care. The review aims to provide a practical, patient-friendly perspective suitable for researchers, clinicians, and students.
KEYWORDS: Recurrent aphthous stomatitis (RAS)Polyherbal mouthwashes, Glycyrrhiza glabra, aphthous ulcers, tulsi etc.
Cite This Article:
Please cite this article in press Maviya Choudhari et al., A Review Article On Polyherbal Mouthwash To Apthour Ulcer, Indo Am. J. P. Sci, 2025; 12(11).
REFERENCES:
1. Ajay S. Dongarwar, Dinesh P. Borkar and etal. Formulation and Evaluation of Herbal Aqueous Gel Form Mouth Ulcer. European Journal of Pharmaceutical and Medical Research, 2022:9(7), 256-262.
2. Miss. Harshada B. Tribhuvan, Miss. Sapana S. Mhaske and etal. Formulation and Evaluation of Pharmaceutical Aqueous Gel for Mouth Ulcer Treatment: International Journal of Scientific Research in Science and Technology,2022:9(4),34-40.
3. Loic Vaillant, Mahtab Samimi Presse Medicale (Paris, France: 1983) 45 (2), 215-226, 2016
4. D. Harris, J.R. Robinson, Drug Delivery via the Mucous Membranes of the Oral Cavity, Journal of Pharma Sciences. (1992):81: 1-10.
5. Nazila Salamat-Miller, Montakarn Chitt Chang, Thomas P, Johnston, The use of Mucoadhesive Polymers in Buccal Drug Delivery, Advanced Drug Delivery Reviews Elsevier (2005); 57:1666-1691.
6. Mandel, T. D. Chemotherapeutic agents for controlling plaque and gingivitis.
7. Van Der Weijden, F.A. Et al Can Chemical Mouthwash Agents Achieve Plaque Gingivitis Control” KEYWORDS Dental plaque Gingivitis Mouthwash Mouthrinse Systematic review Meta-review KEY POINTS. Dent. Clin. NA 59, 799-829 (2015).
8. Kilian, M. Et al. The oral microbiome-An update for oral healthcare professionals. Br. Dent. J. 221. 657-666 (2016).
9. Farah, C. S., Mcintosh, L. & McCullough, M. J. Mouthwashes. Australian Prescriber vol. 32 162-164 (2009)
10. Chye, R. M. L.. Perrotti, V., Piattelli, A., laculli, F. & Quaranta, A. Effectiveness of Different Commercial Chlorhexidine-Based Mouthwashes after Periodontal and Implant Surgery: A Systematic Review. Implant Dentistry vol. 28 74-85 (2019).
11. Joshipura, K. J., Mu Noz-Torres, F. J., Morou-Bermudez, E. & Patel, R. P. Over-the-counter mouthwash use and risk of pre-diabetes/diabetes. Nitric Oxide 71, 14-20 (2017).
12. Periodontal Disease | Oral Health Conditions Division of Oral Health CDC. Center for Disease Control and Prevention https://www.cdc.gov/oralhealth/conditions/periodontal-disease.html
13. Chapple, 1. L. C. Et al. Primary prevention of periodontitis: managing gingivitis. J Clin Periodontal 42, 71-76(2015).
14. S. S. Et al. Comparative Evaluation of Cocoa Bean Husk, Ginger and Chlorhexidine Mouth Washes in the Reduction of Streptococcus Mutans and Lactobacillus Count in Saliva. A Randomized Controlled Trial. Cureus 11. (2019).
15. American Dental Association. Mouthwash (Mouthrinse), http://www.ada.org/em/member-cental/oral-health-topics/mouthrinse (2019).
16. Chlorhexidine C22H30C12N10-PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/9552079
17. Elkerbout, T., Slot, D., Van Loveren, C. & Van der Weijden, G. Will a chlorhexidine-fluoride mouthwash reduce plaque and gingivitis Int. J. Dent. Hyg. 17, 3-15 (2019).
18. Banu NJ and Gayathri V. Preparation of Antibacterial Herbal Mouthwash Against Oral Pathogen. International Journal of Current Microbiology and Applied Sciences 2016; 5(11):205-221
19. Varalakshmi. E. Ramya. A Study to Assess Effectiveness of The Guava Leaves Mouthwash for Patients with Oral Problems. International Journal of Engineering Research and General Science Sept-Осt2019;7(5):35-42
20. Takenaka S, Ohsumi T, Noiri Y. Evidence Based Strategy for Dental Biofilms: Current Evidence Of Mouthwashes On Dental Biofilm And Gingivitis. Japnese Dental Science Review 2019,55:33 40
21. Jalaluddin Md. Rajaekaran UB, Paul S, Dhanya RS, Sudeep CB, Adarsh VI. Comparative Evaluation of Neem Mouthwash on Plaque And Gingivitis: A Double Blind Crossover Study. The Journal of Contemporary Dental Practice. July 2017;18(7):567-568.
22. Ashwin. K.S. Karthikeyan. M, Nirmalkumar. R. Rajanivetha, Priyadarshini. R. Halitosis: a Short Review. Research J. Pharm. and Tech. 7(12): Dec. 2014; Page 1494-1497
23. Raj D. Thangavelu L, Ganapathy D. Herbal Mouthwash. Drag Invention Today 2019, 12(10):2325-2328.
24. http://ensuredentalcare.comadvantages-and-disadvantages-of-mouthwash/
25. Lakshmi T, Krishna V. Rajendra R. Azadirachta Indica. A. Herbal Panacea In Dentistry- an update Pharmacognosy Reviews. Jan-june 2015:9(17):41-44.
26. Hosamane M, Acharya AB. Evaluation of Holy Basil Mouthwash as An Adjunctive Plaque Control Agent in Afour Day Plaque Regrowth Model. Journal Clinical Experimental Dentistry 2014:6(5):491-e496.
27. Banu NJ and Gayathri V. Preparation of Antibacterial Herbal Mouthwash Againt Oral Pathogen. International Journal of Current Microbiology and Applied Sciences 2016; 5(11):205-221.
28. Thombre N. Thete M, Shimpi P. Review on Role of Herbs in Management of Oral diseases. Asian J. Pharm. Res. 2020; 10(4):321-326. Doi: 10.5958/2231-5691 2020.00055.6
29. Durbar U, Geetha R.V. Antibacterial Effects of South Indian Spices on Oral Microbes. Research 1. Pharm. And Tech, 8(8): August, 2015; Page 1135-1136. Doi: 10.5958/0974-360X 2015.00201.2.
30. Shankar S. Gopinath P, E. Roja. Role of Spices and Herbs in Controlling Dental Problems. Research Journal of Pharmacology and Pharmacodynamics. 2022;14(1):23-8. Doi: 10.52711/2321-5836.2022.00004.
31. Shah B and Seth AK. Textbook Of Pharmacognosy and Phytochemistry. 1sTEdition Elsevier 238-240,259-260,284-285,290-291,306-307-315-316489-490,551-552.
32. Prashar D, Jasra K. Pharmacognostic, Phytochemical and Therapeutic Overview of three Allied Herbs used in Dentistry. Asian Journal of Research in Pharmaceutical Sciences. 2021; 11(2):121-5. Doi: 10.52711/2231-5659.2021-11-2-5.
33. Reddy Dr H And Dr. Preethi Herbal Mouthwashes. European Journal of Nmolecule and Clinical Medicine 2020:7(2):6655-6661.
34. Anushri M. Yashoda R. Puranik M. Herbs: A Good Alternative to Current Treatments For Oral Health Problems. International Journal of Advance Health Science. April 2015;1(12):26-32




