53.Issue 11 november 25 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 12, Issue : 11, November – 2025

Title:

FORMULATION AND IN VITRO EVALUATION OF BETAHISTINE DIHYDROCHLORIDE CONTROLLED RELEASE TABLETS

Authors :

A. Manaswi *, Dr. K Balaji, Dr. Bigala Raj Kamal.

Abstract :

The objective of the present study was to investigate the effect of various concentrations of polymers on in vitro drug release from controlled release matrix tablets. HPC 2M, HEC 2M and HPMC K 15M. were used as synthetic (hydrophilic) polymers respectively. Betahistine Dihydrochloride was used as a model drug to study the in vitro release profile. Matrix tablets of Betahistine Dihydrochloride were fabricated by varying the concentrations of synthetic polymers via direct compression method. The results of all evaluation parameters of the matrix tablet were within the acceptable limit. A significant difference was observed on in vitro drug release due to difference in polymers and their concentration. HEC 2M in the concentration of 8 mg showed 99.82 % cumulative drug release at the end of 12 h. The release mechanism of matrix tablet followed zero order release kinetics. On comparing in vitro release of optimized formulation with other preparations, it was concluded that F5 was found to be more efficient and promising than other preparations.
Keywords: Betahistine Dihydrochloride, HPC 2M, HEC 2M and HPMC K 15M, Controlled release tablets.

Cite This Article:

Please cite this article in press A. Manaswi et al., Formulation And In Vitro Evaluation Of Betahistine Dihydrochloride Controlled Release Tablets, Indo Am. J. P. Sci, 2025; 12(11).

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