Volume : 12, Issue : 11, November – 2025
Title:
SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NOVEL 3-[(2-SUBSTITUTED-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[b]THIENO [2,3-d] PYRIMIDIN-4-YL) AMINO] PROPAN-1-OL
Authors :
Chamakuri Srikanth, Dr.K. Hariprasad, Dr. L. Harikiran.
Abstract :
4-Chloro thienopyrimidines were treated with aminopropanol to give corresponding aminopropanol derivatives (4a-4d), title compounds in good yields.The conventional method of preparation of 3-[(2-substituted-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[2,3-d]pyrimidin-4-yl)amino]propan-1-ol was compared with microwave assisted method with respect to their reaction time and yield.All the compounds synthesized were characterized by physical (Rf values, M.P., Molecular weight, molecular formula), spectral data (1H NMR, 13C NMR, MASS).
The title compounds were screened for anticancer activity by MTT assay and analyzed statistically.
Compounds showed considerable anticancer activity when compared with cyclophosphamide.
Further lead optimization should be carried out for the better expected anticancer activity.
Cite This Article:
Please cite this article in press Chamakuri Srikanth et al., synthesis and anticancer activity of some novel 3-[(2-substituted-6,7,8,9-tetrahydro-5h-cyclohepta[b]thieno [2,3-d] pyrimidin-4-yl) amino] propan-1-ol, Indo Am. J. P. Sci, 2025; 12(11).
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