Volume : 12, Issue : 11, November – 2025
Title:
SYNTHESIS, CHARACTERIZATION AND EVALUATE THE BIOLOGICAL ACTIVITY OF SOME OF NOVEL 1,3,4-THIADIAZOLE DERIVATIVES
Authors :
Vanamdas Sainath Goud, G. Swetha Reddy, Dr. L. Harikiran.
Abstract :
Synthetic work of the studies could go positively as per the planning and as such in all the reactions carried out. The expected compounds alone could be obtained.
Newly synthesized compounds were characterized by TLC, IR, ¹H-NMR and Mass spectral analysis.
New 1,3,4-Thiadiazole derivatives showed promising antimicrobial activity. Compounds Methyl and Fluorine derivatives were found to be the more potent antibacterial activity respectively towards gram positive (Micrococcus luteus) and gram negative (klebsiella pneumonia)
New Benzimidazole derivatives showed promising antioxidant activity. Compounds (R=F) & (R= CH3) were found to be more potent antioxidant compounds among the all test compounds.
Cite This Article:
Please cite this article in press Vanamdas Sainath Goud et al., Synthesis, Characterization And Evaluate The Biological Activity Of Some Of Novel 1,3,4-Thiadiazole Derivatives, Indo Am. J. P. Sci, 2025; 12(11).
REFERENCES:
1. Kaushal M, Kaur A. A review on some 2,5-disubstituted [1,3,4] thiadiazole substituted thiazolidinone derivatives as a potent antimicrobial agents. World J Pharm Res. 2016;5(6):1966–77.
2. Mehta D, Taya P Neetu, author. A review on the various biological activities of thiadiazole. Int J Pharm Pharm Sci. 2015;7(4):39–47.
3. Rao MRK, Shil S. Some observations on thin layer chromatography technique. Int J Recent Technol Eng. 2019;8(2):1700–2.
4. Sandeep Kumar Reddy C, Azam Khan KK, Nagaraja C. A review on the determination of melting point measurement system. Int J Adv Res Electr Electron Instrum Eng. 2016;5(2):975–9.
5. Furniss BS, Vogel AI. Vogel’s textbook of practical organic chemistry. 5th ed. Pearson/Prentice Hall; Harlow: 2009. pp. 236–8.pp. 1204–10.
6. Serban G, Stanasel O, Serban E, Bota S. 2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents. Drug Des Devel Ther. 2018;12:1545–66. doi: 10.2147/DDDT.S155958.
7. Kaur P. 1,3,4-thiadiazole and its derivatives: a review on biological activities. Int J Univ Pharm Bio Sci. 2017;6(3):246–80.
8. Abo-Bakr AM, Hashem HE. New 1,3,4-thiadiazole derivatives: synthesis, characterization, and antimicrobial activity. J Heterocycl Chem. 2019;56(3):1038–47.
9. Parmar KC, Umrigar NH. Review article on synthesis of 1,3,4- thiadiazole derivatives and it’s biological activity. J Chem Pharm Res. 2017;9(6):202–14.
10. Adnan S, Mohammed AJ, Thamer H. Synthesis and identification of some derivatives of 1,3,4-thiadiazole. J Chem Pharm Res. 2015;7(10):1000–11.
11. Sayed A, Zaki Y, Aish E. A convenient route for the synthesis of new thiadiazoles. Turk J Chem. 2016;40(1):184–91.
12. Syed MA, Reddy YRP, Chandrasekhar KB. Design, one-pot synthesis and biological evaluation of imidazo[2,1-b] [1,3,4] thiadiazole Derivatives for their anti-tubercular and antifungal activity. J App Pharm Sci. 2018;8(7):21–7.
13. Jain AK, Sharma S, Vaidya A, Ravichandran V, Agrawal RK. 1,3,4-thiadiazole and its derivatives: a review on recent progress in biological activities. Chem Biol Drug Des. 2013;81(5):557–76. doi: 10.1111/cbdd.12125.
14. U. Kalidhar and A. Kaur, 1,3,4-Thiadiazole derivatives and their biological activities: A review, Res. J. Pharm., Biol. Chem. Sci., 2011, 2, 1091–1106 CAS.
15. S. Georgeta, S. Oana, S. Eugenia and B. Sanda, 2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents, Drug Des., Dev. Ther., 2018, 12, 1545–1566 CrossRef PubMed.
16. S. Haider, M. S. Alam and H. Hamid, 1,3,4-Thiadiazoles: A potent multi targeted pharmacological scaffold, Eur. J. Med. Chem., 2015, 92, 156–177 CrossRef CAS PubMed.
17. M. Amir, A. Kumar, I. Ali and S. A. Khan, Synthesis of pharmaceutically important 1,3,4-thiadiazole and imidazolinone derivatives as antimicrobials, Indian J. Chem., 2009, 48B, 1288–1293 CAS.
18. J. Salimon, N. Salih, A. Hameed, H. Ibraheem and E. Yousif, Synthesis and antibacterial activity of some new 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives, J. Appl. Sci. Res., 2010, 6(7), 866–870 CAS.
19. E. E. Oruc, S. Rollas, F. Kandemirli, N. Shvets and A. Dimoglo, 1,3,4-Thiadiazole derivatives. Synthesis, structure elucidation and structure-antituberculosis activity relationship investigation, J. Med. Chem., 2004, 47(27), 6760–6767
20. S. Schenone, C. Brullo and O. Bruno, et al., New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities, Bioorg. Med. Chem., 2006, 14(6), 1698–1705
21. L. Labanauskas, V. Kalcas, E. Udrenaite, P. Gaidelis, A. Brukstus and A. Dauksas, Synthesis of 3-(3,4-dimethoxy phenyl)-1H-1,2,4-triazole-5-thiol and 2-amino-5-(3,4-dimethoxy phenyl)-1,3,4-thiadiazole derivatives exhibiting anti-inflammatory activity, Pharmazie, 2001, 56, 617–619 CAS.
22. H. Khalilullah, M. U. Khan, D. Mahmood, J. Akhtar and G. O. Elhassan, 1,3,4-Thiadiazole: A biologically active scaffold, Int. J. Pharm. Pharm. Sci., 2014, 6, 8–15 CAS.
23. S. R. Pattan, N. S. Desai, P. A. Rabara, A. A. Bukitgar and V. A. Wakale, Synthesis and antimicrobial evaluation of some 1,3,4-thiadiazole derivatives, Indian J. Pharm. Educ. Res., 2008, 42(4), 314–318.
24. A. Basso, M. Liu and C. Dai, et al., SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics, Mol. Cancer Ther., 2010, 9(11), 2993–3002
25. S. S. Taha, A. A. Ahmad, S. I. Mawlood and N. O. Ali, Synthesis of some series of 2-amino-1,3,4-thiadiazole derivatives with their pathogenic bacterial activity, J. Raparin Univ., 2017, 4(11), 63–78.
26. A. A. Kadi, E. S. Al-Abdullah, I. A. Shehata, E. E. Habib, T. M. Ibrahim and A. A. El-Emam, Synthesis, antimicrobial and anti-inflammatory activities of novel 5-(1-adamantyl)-1,3,4-thiadiazole derivatives, Eur. J. Med. Chem., 2010, 45(11), 5006–5011.
27. M. Gür, M. Muğlu, M. S. Çavuş, A. Güder, H. S. Sayiner and F. Kandemirli, Synthesis, characterization, quantum chemical calculations and evaluation of antioxidant properties of 1,3,4-thiadiazole derivatives including 2-and 3-methoxy cinnamic acids, J. Mol. Struct., 2017, 1134, 40–50.
28. A. A. Othman, M. Kihel and S. Amara, 1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agents, Arabian J. Chem., 2014, 12, 1660–1675
29. J. Y. Chou, S. Y. Lai, S. L. Pan, G. M. Jow, J. W. Chern and J. H. Guh, Investigation of anticancer mechanism of thiadiazole-based compound in human nonsmall cell lung cancer A549 cells, Biochem. Pharmacol., 2003, 66, 115–124.
30. A. Kaur, R. Kumar and U. Kalidhar, Synthesis, spectral studies and biological activity of some novel biphenyl imidazo[2,1-b][1,3,4]thiadiazole derivatives, Res. J. Pharm., Biol. Chem. Sci., 2012, 3, 1084–1096.