Volume : 12, Issue : 11, November – 2025
Title:
PSORALEA CORYLIFOLIA L. (BAKUCHI): A COMPREHENSIVE REVIEW ON PHARMACOGNOSY, PHYTOCHEMISTRY, PHARMACOLOGY, AND THERAPEUTIC POTENTIAL IN SKIN DISORDERS
Authors :
V.Alekhya*, S.Udaya Lakshmi, V.Sai kishore
Abstract :
Psoralea corylifolia L. (commonly known as Bakuchi or Babchi) is a well-documented medicinal plant in Ayurveda, Unani, and Chinese medicine, primarily recognized for its therapeutic role in dermatological conditions, including psoriasis, vitiligo, and leprosy. The seeds and other plant parts are rich in furanocoumarins, flavonoids, meroterpenes, and essential oils, which contribute to its diverse pharmacological actions such as antimicrobial, anti-inflammatory, antioxidant, antitumor, and hepatoprotective properties. This review aims to provide an updated and comprehensive understanding of P. corylifolia by discussing its botany, traditional uses, phytochemical composition, extraction methods, pharmacological studies, and clinical applications. It is an annual herb of the genus Psoralea in the family Fabaceae, and its mature fruit can be used medicinally as a precious medicinal herb to tonify muscles and bones. With the deepening of research, its applications to various industries, including food, agriculture, and cosmetics, with products being developed in countries such as Vietnam, India, and Japan. PCL and related products have demonstrated therapeutic effects, such as antiosteoporosis effects, estrogen-like effects, anti-inflammatory properties, neuroprotection, antitumor activity, and vitiligo treatment. The expression mechanisms of these pharmacological effects are closely related to the regulation of the immune system, the inhibition of oxidative stress, and the induction of apoptosis. This paper summarizes the latest research on the ethnobotany, phytochemistry, processing technology, pharmacology, and hepatotoxicity of PCL. Furthermore, bibliometric analysis was used to systematically analyze the research hotspots and trends in PCL, which have never been addressed in previous reviews of PCL. In the future, it will be necessary to focus on the active metabolites of PCL, analyze its targets and signaling pathway network to address potential toxicity and side effects in clinical applications, and further expand the potential application of PCL in medicine.
Cite This Article:
Please cite this article in press V.Alekhya et al., Psoralea corylifolia l. (bakuchi): a comprehensive review on pharmacognosy, phytochemistry, pharmacology, and therapeutic potential in skin disorders, Indo Am. J. P. Sci, 2025; 12(11).
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