Volume : 12, Issue : 10, October – 2025

Title:

NASAL TO BRAIN DRUG DELIVERY SYSTEM: AN OVERVIEW

Authors :

Damayanthi Singanaboina, L Satyanarayana

Abstract :

Delivery from the nose to the brain is a significant difficulty. Numerous neurological conditions really call for treatments where the medication must enter the brain without encountering the blood-brain barrier (BBB) or issues related to systemic administration, such drug bioavailability, and adverse effects. Compared to oral administration, which can lead to unacceptable low drug bioavailability, or parenteral administration, which can occasionally be unpleasant, intra-nasal delivery of medications offers an intriguing alternative for attaining systemic therapeutic benefits. Therefore, it is critical to comprehend the advantages and disadvantages of different nasal medication delivery systems. However, nasal administration also has some limitations, such as its low bioavailability due to metabolism on the mucosal surface, and irreversible damage to the nasal mucosa due to the ingredients added into the formula. Moreover, the method of nasal administration is not applicable to all drugs. The present paper discussed the nasal anatomy, history of nasal to brain drug delivery systems, and its mechanism. Nevertheless, nasal administration of drugs in order to bypass the BBB and facilitate direct entry of a drug into the CSF or brain tissue is still a safe, convenient, and non-destructive method of targeted drug delivery to the CNS.
Key words: Nasal to brain, central nervous system, respiratory region, Traditional Chinese Medicine, columnar epithelium.

Cite This Article:

Please cite this article in press L. Satyanarayana et al Nasal To Brain Drug Delivery System: An Overview, Indo Am. J. P. Sci, 2025; 12(10).

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