Volume : 12, Issue : 10, October – 2025

Title:

NOVEL APPROACHES TO PAIN MANAGEMENT FOR ACUTE MUSCULOSKELETAL INJURIES: A REVIEW OF THE LITERATURE
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Authors :

 

Abstract :

Acute musculoskeletal injuries are a leading cause of global disability, and their management has been heavily reliant on conventional analgesics like opioids and NSAIDs, which are associated with significant risks including dependency and adverse effects. This necessitates a critical evaluation of novel, safer, and more effective pain management strategies. This review aims to synthesize current evidence on innovative approaches to managing acute musculoskeletal pain, focusing on multimodal, interventional, and preventative strategies that move beyond traditional pharmacological methods. A comprehensive literature search was conducted in PubMed, MEDLINE, Cochrane Library, Embase, and Scopus for studies published from January 2010 to June 2023. Seventeen studies, including systematic reviews, narrative reviews, and clinical guidelines, meeting the inclusion criteria were selected for a narrative synthesis. The findings reveal a paradigm shift towards a multifaceted paradigm. Key innovations include: 1) Novel pharmacological and biotechnological strategies, such as non-opioid drug targets and orthobiologics (e.g., Platelet-Rich Plasma); 2) Advanced interventional and rehabilitative modalities, including targeted nerve blocks and technology-assisted personalized rehab; and 3) Systems-level and preventative approaches, emphasizing early intervention, ergonomic prevention, and biopsychosocial models to avert the transition to chronic pain. The management of acute musculoskeletal pain is evolving into a proactive, multimodal, and personalized framework. Effective care requires integrating novel pharmacology, regenerative medicine, precise interventions, and preventative strategies. Future efforts should focus on high-quality trials, cost-effectiveness analyses, and implementation science to translate these evidence-based approaches into widespread clinical practice.
Keywords: Acute Musculoskeletal Pain, Multimodal Analgesia, Orthobiologics, Pain Management, Preventive Medicine

Cite This Article:

Please cite this article in press Fahad Mohammad Salem Bahashwan et al., Novel Approaches To Pain Management For Acute Musculoskeletal Injuries: A Review Of The Literature, Indo Am. J. P. Sci, 2025; 12(10).

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