112.Issue 10 october 25 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 12, Issue : 10, October – 2025

Title:

FENUGREEK- AN ANTIDIABETIC HERBAL DRUG

Authors :

Rohan R. Munde, Ms. Ankita Sarnaik, Dr. Swati Deshmukh

Abstract :

Fenugreek (Trigonella foenum-graecum L.) is an important medicinal herb belonging to the family Fabaceae, widely known for its antidiabetic potential. Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, primarily due to insulin resistance or deficiency. Fenugreek seeds contain several bioactive compounds such as alkaloids, flavonoids, saponins, and amino acids that contribute to their hypoglycemic activity. Among these, 4-hydroxyisoleucine enhances insulin secretion, while galactomannan delays glucose absorption. The plant also exhibits antioxidant, hypolipidemic, and anti-inflammatory activities that help manage diabetic complications. Traditional systems of medicine, including Ayurveda and Chinese medicine, have long used fenugreek as a natural remedy. Various extraction methods such as Soxhlet and maceration are employed to isolate its active constituents. Pharmacological studies support its role in reducing blood sugar and cholesterol levels. Marketed formulations like capsules, powders, and churnas further confirm its therapeutic importance. Fenugreek is generally safe but should be used cautiously during pregnancy. Overall, it represents a promising herbal alternative for managing Type 2 diabetes mellitus and related metabolic disorders.
Keywords: Fenugreek, Trigonella foenum-graecum, Antidiabetic activity, Hypoglycemic effect, Herbal medicine, Galactomannan, 4-Hydroxyisoleucine, Saponins, Flavonoids, Type 2 diabetes mellitus, Phytochemical constituents, Traditional medicine.

Cite This Article:

Please cite this article in press Rohan R. Munde et al., Fenugreek- An Antidiabetic Herbal Drug, Indo Am. J. P. Sci, 2025; 12(10).

REFERENCES:

1. Cho, N.H., Shaw, J.E., Karuranga, S., Huang,Y., da Rocha Fernandes, J.D., Ohlrogge, A.W. and Malanda B. (2018) IDF Diabetes Atlas: Global Estimates of Diabetes Prevalence for 2017 and Projections for 2045. Diabetes Research and Clinical Practice, 138, 271-281.
2. Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B.B., et al. (2022) IDF Diabetes Atlas: Global, Regional and Country-Level Diabetes Prevalence Estimates for 2021 and Projections for 2045. Diabetes Research and Clinical Practice, 183, 109-119.
3. Holman N, Young B, Gadsby R. Current prevalence of Type 1 and Type 2 diabetes in adults and children in the UK. Diabet Med.2015;32:1119-1120.
4. Adeshara KA, Diwan AG, Tupe RS. Diabetes and complications: cellular signaling pathways, current understanding and targeted therapies. Curr Drug Targets. 2016;17:1309-1328.5.
5. Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of Type 2 diabetes mellitus and its complications. Nat Rev Endocrinol.2018;14:88- 98.6.
6. Jacobs E, Hoyer A, Brinks R, Icks A, Kuß O, Rathmann W. Healthcare costs of Type 2 diabetes in Germany. Diabet Med. 2017;34:855-861.7.
7. Seuring T, Archangelidi O, Suhrcke M. The economic costs of Type 2 diabetes: a global systematic review. Pharmacoeconomics.2015;33:811-831.8.
8. Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac JTrop Biomed. 2012;2:320-330.9.
9. Idris S, Mishra A, Khushtar M. Recent therapeutic interventions of fenugreek seed: a mechanistic approach. Drug Res (Stuttg).2021;71:180-192.10.
10. Nagulapalli Venkata KC, Swaroop A, Bagchi D, Bishayee A. A small plant with big benefits: fenugreek (Trigonella foenum-graecum Linn.)for disease prevention and health promotion. Mol Nutr Fo2017;61:61.
11. Basch, E., Ulbricht, C., Kuo, G., Szapary, P. And Smith, M. (2003) Therapeutic Application of Fenugreek. Alternative Medicine Review, 8, 20-27.
12. Khodamoradi K, Khosropanah MH, Ayati Z, et al. The effects of Fenugreek on cardiometabolic risk factors in adults: a systematic Review and meta-analysis. Complement Ther Med. 2020;52:102416.
13. Heshmat-Ghahdarijani K, Mashayekhiasl N, Amerizadeh A, Teimouri Jervekani Z, Sadeghi M. Effect of fenugreek consumption on serum lipid profile: A systematic review and meta-analysis. Phytother Res. 2020;34:2230-2245.
14. Haber SL, Keonavong J. Fenugreek use in patients with diabetes Mellitus. Am J Health Syst Pharm. 2013;70(14):1196-1203.
15. Ouzir M, El Bairi K, Amzazi S. Toxicological properties of fenugreek (Trigonella foenum graecum). Food Chem Toxicol. 2016;96:145-154.
16. Bahmani M, Shirzad H, Mirhosseini M. Mesripour A, Rafieian-Kopaei M. A review on ethnobotanical and therapeutic uses of fenugreek (Trigonella foenum-graceum L). J Evid Based Complementary Altern Med. 2016;21:53-62.
17. Zameer S, Najmi AK, Vohora D, Akhtar M. A review on therapeutic potentials of Trigonella foenum graecum (fenugreek) and its chemical constituents in neurological disorders: Complementary roles to its hypolipidemic, hypoglycemic, and antioxidant potential. Nutr Neurosci. 2018:21:539-545.
18. Kokate, C. K., Purohit, A. P., & Gokhale, S. B. (2021). Pharmacognosy (53rd ed.). Nirali Prakashan, Pune, pp. 1.75–1.76.
19. Kokate, C.K., Purohit, A.P., & Gokhale, S.B. (2019). Pharmacognosy (50th ed., p. 270). Nirali Prakashan, Pune.
20. Picke AK, Campbell G, Napoli N, Hofbauer LC, Rauner M. Update on the impact of type 2 diabetes mellitus on bone, metabolism and material properties. Endocr Connect. 2019 Mar 01:8(3):R55-R70.
21. Pauza AG, Thakkar P, Tasic T, Felippe I, Bishop P, Greenwood MP, Rysevaite-Kyguoliene K, Ast J, Broichhagen J, Hodson DJ, Salgado HC, Pauza DH, Japundzic-Zigon N, Paton JFR, Murphy D. GLP1R attenuates sympathetic response to high glucose via carotid body inhibition. Circ Res. 2022;130(5):694–707.
22. American Diabetes Association Professional Practice Committee. (2025).
23. Visuvanathan, T.; Than, L.T.L.; Stanslas, J.; Chew, S.Y.; Vellasamy, S. Revisiting Trigonella Foenum-graecum L.: Pharmacology And Therapeutic Potentialities. Plants 2022
24. Srinivasan, K. Fenugreek (Trigonella foenum-graceum): A Review of Health Beneficial Physiological Effects. Food Rev. Int. 2006, 22, 203–224.
25. Sowmya, P.; Rajyalakshmi, P. Hypocholesterolemic effect of germinated fenugreek seeds in human subjects. Mater. Veg. 1999, 53, 359–365.
26. Dharajiya, D.; Jasani, H.; Khatrani, T.; Kapuria, M.; Pachchigar, K.; Patel, P. Evaluation of Antibacteria and Antifungal Activity of Fenugreek (Trigonella foenum-graceum) Extracts. Int. J. Pharm. Pharm. Sci. 2016, 8, 212–217.
27. Wani, S.A.; Kumar, P. Fenugreek: A review on its nutraceutical properties and utilization in various food products. J. Saudi Soc. Agric. Sci. 2018, 17, 97–106.
28. Khorshidian, N., Yousefi Asli, M., Arab, M., Adeli Mirzaie, A., & Mortazavian, A. M. (2016). Fenugreek: Potential applications as a functional food and nutraceutical. Nutrition and Food Sciences Research, 3(1), 5–16.
29. Pandey A, Tripathi S. Concept of standardization, extraction, and pre-phytochemical screening strategies for herbal drug. J Pharmacogn. Phytochem. 2014;2:115-9
30. Sasidharan S. Chen Y, Saravanan D, Sundram KM, Yoga Latha L. Extraction, isolation and characterization of bioactive compounds from plants extracts. Afr J Tradit Complement Altern Med. 2011:8:1-10
31. Suman, R., & Kumari, A. (2020). Extraction and Phytochemical Screening of Fenugreek (Trigonella foenum-graecum L.) Seeds. International Journal of Pharmaceutical Sciences Review and Research, 64(2), 45–49.
32. Kumar A, Aswal S, Chauhan A, Semwal RB, Kumar A and Semwal DK: Ethnomedicinal investigation of medicinal plants of Chakrata region (Uttarakhand) used in the traditional medicine for diabetes by Jaunsari tribe. Nat Prod Bioprospect. 9:175–200. 2019.
33. Ota A and Ulrih NP: An overview of herbal products and secondary metabolites used for management of type two diabetes. Front Pharmacol. 8(436)2017.
34. Raghuram, T.C.; Sharma, R.D.; Sivakumar, B.; Sahay, B.K. Effect of fenugreek seeds on intravenous glucose disposition in non-insulin dependent diabetic patients. Phytotherapy Res. 1994, 8, 83–86
35. Snehlata, H.; Payal, D. Fenugreek (Trigonella foenum-graecum L): An overview. Int. J. Curr. Pharm. 2012,2, 169-187.
36. Abdelwahab, N.S.; Morsi, A.; Ahmed, Y.M.; Hassan, H.M.; AboulMagd, A.M. Ecological HPLC method for analyzing an antidiabetic drug in real rat plasma samples and studying the effects of concurrently administered fenugreek extract on its pharmacokinetics. RSC Adv. 2021, 11, 4740–4750.
37. Basch E, Ulbricht C, Kuo G, Szapary P, Smith M. Therapeutic applications of fenugreek. Altern Med Rev. 2003;8(1):20–27.
38. Srinivasan K. Fenugreek (Trigonella foenum-graecum): A review of health beneficial physiological effects. Food Chem. 2018;259:215–222.
39. Dixit P, Ghaskadbi S, Mohan H, Devasagayam TP. Antioxidant properties of germinated fenugreek seeds. Phytother Res. 2005;19(11):979–983.
40. Raju J, Bird RP. Alleviation of hepatic and metabolic abnormalities by fenugreek in experimental models. J Nutr Biochem. 2001;12(11):611–619.
41. Shabana SM, El-Menshawi BS, Refaat A, et al. Potential anticancer activity of fenugreek seed extracts. Cancer Biol Ther. 2013;14(12):1120–1129.
42. Bukhari SA, Iqbal Z, Hanif MA, et al. Gastroprotective effect of fenugreek seeds in experimental ulcer models. J Ethnopharmacol. 2008;114(3):396–401.
43. Turkyilmaz C, Onal E, Hirfanoglu IM, et al. The effect of galactagogue herbal tea containing fenugreek on breast milk production. J Altern Complement Med. 2011;17(2):139–142.
44. Haxhiraj, M.; White, K.; Terry, C. The Role of Fenugreek in the Management of Type 2 Diabetes. Int. J. Mol. Sci. 2024, 25, 6987.
45. Himalaya Wellness Company. Fenugreek Capsules – Product Information. Himalaya Drug Company, India. Available at: https://himalayawellness.in
46. Organic India Pvt. Ltd. Methi Powder – Product Description. Organic India, Lucknow, India. Available at: https://www.organicindia.com
47. Shree Baidyanath Ayurved Bhawan. Methi Plus Tablets – Product Information Leaflet. Baidyanath, India. Available at: https://www.baidyanath.co.in
48. Jiva Ayurveda. Methi Churna – Product Details. Jiva Ayurveda, Faridabad, India. Available at: https://www.jiva.com
49. Nature’s Way. Fenugreek Seed Capsules – Official Product Page. Nature’s Way Products, USA. Available at: https://www.naturesway.com
50. Alu’datt, M. H., Rababah, T., Al-ali, S., Tranchant, C. C., Gammoh, S., Alrosan, M., Kubow, S., Tan, T.-C., & Ghatasheh, S. (2024). Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications. Journal of Food Science, 89, 1835-1864.