116.Issue 10 october 25 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 12, Issue : 10, October – 2025

Title:

FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF NARATRIPTAN

Authors :

Shireen Fatima, Dr. Abdul Sayeed, Dr. Syed Areefulla Hussainy, Dr. Faizan Sayeed

Abstract :

The present study was aimed at the formulation development and evaluation of mucoadhesive buccal tablets of Naratriptan to enhance its bioavailability and therapeutic efficacy in the treatment of migraine. Naratriptan undergoes extensive first-pass metabolism, resulting in reduced oral bioavailability; hence, buccal delivery was chosen as an alternative route to bypass hepatic metabolism and provide sustained drug release. Mucoadhesive buccal tablets were prepared using various natural and synthetic polymers such as Sodium starch glycolate, Crospovidone and Croscarmellose sodium by direct compression method.
The formulations were evaluated for pre-compression parameters (bulk density, tapped density, angle of repose) and post-compression parameters (hardness, thickness, friability, drug content, surface pH, swelling index, mucoadhesive strength, and in vitro drug release). All evaluation parameters were found within the acceptable limits. Among the developed formulations, F4 was identified as the optimized formulation, showing a maximum drug release of 99.72 % over 8 hours along with excellent mucoadhesive properties and sustained release profile.
The results of this study indicate that mucoadhesive buccal tablets of Naratriptan offer a promising approach for improving bioavailability and achieving prolonged therapeutic effect in migraine therapy.
Keywords: Naratriptan , Sodium starch glycolate, Crospovidone and Croscarmellose

Cite This Article:

Please cite this article in press Shireen Fatima et al., Formulation Development And Evaluation Of Mucoadhesive Buccal Tablets Of Naratriptan, Indo Am. J. P. Sci, 2025; 12(10).

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