Volume : 12, Issue : 10, October – 2025
Title:
KIDNEY STONES: FROM PATHOGENESIS TO PREVENTION – A CRITICAL REVIEW
Authors :
Pranjali A. Bagde*, Mr. Narayan R. Kalve, Dr. Swati P. Deshmukh
Abstract :
The goal of this review was to assemble the most recent data on kidney stone etiology, pathophysiology, and preventative strategies. One of the earliest recognized medical disorders in human history is kidney stone illness, sometimes referred to as nephrolithiasis or urolithiasis. It is a growing urological condition that affects roughly 12% of people worldwide. An imbalance between factors that either promote or inhibit urinary crystallization modulates the multifactorial mechanism of kidney stone formation, a complex process that arises from multiple physicochemical events such as supersaturation, nucleation, growth, aggregation, and retention of urinary stone steps. A higher incidence of urolithiasis is associated with lifestyle variables like sedentary behavior, a high body mass index, and bad eating habits, as well as medical disorders like diabetes and dyslipidemia. In order to diagnose kidney stones, guide treatment choices, and maybe lessen the need for surgery, radiological imaging is essential. This reduces hospital stays and related consequences. By combining data from peer-reviewed literature, this review thoroughly assesses the effectiveness of several radiological imaging modalities in identifying and treating urolithiasis in a range of clinical settings.
Cite This Article:
Please cite this article in press Pranjali Ashok Bagde et al., Kidney Stones: From Pathogenesis To Prevention – A Critical Review, Indo Am. J. P. Sci, 2025; 12(10).
REFERENCES:
1. Finlayson B. Physicochemical aspects of urolithiasis. Kidney Int. 1978;13:344–360.
2. Lopez M, Hoppe B. History, epidemiology and regional diversities of urolithiasis. Pediatr Nephrol. 2008;25(1):49–59.
3. Vijaya T, Kumar MS, Ramarao NV, Babu AN, Ramarao N. Urolithiasis and its causes: Short review. J Phytopharmacol. 2013;2(3):1–6.
4. Taylor EN, Stampfer MJ, Curhan GC. Obesity, weight gain and the risk of kidney stones. JAMA. 2005;293(4):455–462.
5. Wang Z. Recent advances on the mechanisms of kidney stone formation: Review. Int J Mol Med. 2021;48:149.
6. Alelign T, Petros B. Kidney stone disease: An update on current concepts. Adv Urol. 2018;2018:3068365.
7. Malhotra KK. Medical aspects of renal stone. J Indian Acad Clin Med. 2008;9(4):282–284.
8. Shokeir AA. Renal colic: New concepts related to pathophysiology, diagnosis and treatment. Curr Opin Urol. 2002;12(4):263–269.
9. Bawari S, Sah AN, Tewari D. Urolithiasis: An update on diagnostic modalities and treatment protocols. Indian J Pharm Sci. 2017;79(2):164–174.
10. Mazzucchi E, Srougi M. What’s new in the diagnosis and management of urinary lithiasis? Rev Assoc Med Bras. 1992;38(2):XX–XX.
11. Skolarikos A, Straub M, Knoll T, et al. Metabolic evaluation and recurrence prevention for urinary stone patients: EAU guidelines. Eur Urol. 2015;67(4):750–763.
12. Robertson WG, Heyburn PJ, Peacock M, Hanes FA, Swaminathan R. The effect of high animal protein intake on the risk of calcium stone formation in the urinary tract. Clin Sci. 1979;57(3):285–288.
13. Pareta SK. Establishing the principle of herbal therapy for antiurolithiatic activity: A review. J Pharmacol Toxicol. 2011;6(3):321–332.
14. Smith DR. General Urology. New York: Lange Medical Publications; 1978. p. 212–232.
15. Basavaraj DR, Biyani CS, Browning AJ, Cartledge JJ. The role of urinary kidney stone inhibitors and promoters in the pathogenesis of calcium-containing renal stones. BJU Int. 2007;99(6):126–136.
16. Robertson WG, Peacock M, Heyburn PJ, et al. Kidney stone pathophysiology and medical management. Clin Sci. 2006;111(3):333–367.