Volume : 12, Issue : 10, October – 2025
Title:
ARTIFICIAL SWEETENERS AND FOOD COLORANTS THEIR HAZARDOUS IMPACT ON HUMAN HEALTH
Authors :
Kalyani S. Mahalle*, Shivshankar G.Devkunbi, Dr. Swati P. Deshmukh
Abstract :
This review article comprehensively explores the overview of artificial sweeteners and food colorants, examining their safety, regulatory status, and potential health effects. It explores the historical background of artificial sweeteners, covering key compounds like saccharin, aspartame and cyclamate, while also highlighting emerging alternatives such as rare sugars. The discussion extends to the physiological impacts of artificial sweeteners including their potential ill effects on blood glucose levels, obesity, gut microbiome, cardiovascular health, and cancer risk.
Additionally, the review evaluates the safety and adverse effects of food colorants, emphasizing regulatory frameworks and potential health risks associated with synthetic food colorants like tartrazine and rhodamine B. Now a days sugar free food are very much popular because of their less calorie content. So food industry uses various artificial sweeteners which are low in calorie content instead of high calorie sugar. U.S. Food and Drug Administration has approved aspartame, acesulfame-k, neotame, cyclamate and alitame for use as per acceptable daily intake (ADI) value. It concludes by underlining the importance of cautious consumption, particularly among vulnerable populations like children and pregnant women, and advocates for ongoing research to inform evidence-based dietary guidelines and regulatory policies.
Keywords:
Artificial Sweeteners, Food Colorants, Rare Sugar, Diabetes, Obesity, Cancer.
.
Cite This Article:
Please cite this article in press Kalyani S. Mahalle et al., Artificial Sweeteners And Food Colorants Their Hazardous Impact On Human Health, Indo Am. J. P. Sci, 2025; 12(10).
REFERENCES:
1. Kranthi Kumar Poshala, A Review on Artificial sweeteners, International Journal of Engineering Science and computing. 2020; 10(10):27461-27421.
2. Shalini Saxena, A Review on Hazardous effects of synthetic food colors, Journal of Plant Archives. 2023;23(1):218-222.
3. Alessandra Durazzoa, Márcio Carocho et.al., A Review on Food dyes and health: Literature quantitative research analysis, Journal of Measurement Food. 2022;(7)1-7.
4. Rudrajit Paul, Dipanjan Bandyopadhyay, A Review on Are Artificial Sweeteners Safe and Useful: What does the Evidence Suggest, Journal of Indian association of clinical Medicine, 2020;21(3-4): 159-65.
5. Satish Kumar Basattikoppalu Puttegowda, Mohith Shivaramu et.al., A Review on Understanding Artificial Sweeteners and Food Colorants-their Impact on Human Health, Indian Journal of Pharmacy Practice., 2025; 18(1):8-15.
6. Reshma V. Jadhav, Santosh S. Bhujbal, A Review on Natural food colors, Journal of pharmaceutical Resonance 2020; 2(2):1-20.
7. Lydia Kossiva, Kostas Kakleas et.al., Chronic Use of Artificial Sweeteners: Pros and Cons, journal of Nutrients, 2024; (16):1-16.
8. Prithviraj Sadar, Pooja Dande et.al., A Review on Evaluation of Toxicity of Synthetic Food Colors on Human
9. Normal Flora and Yeast, International journal of Health Scienced and Research 2017;7(8)110-114.
10. Tejashree Anil More, Zoya Shaikh and Ahmad Ali et.al., A Review on Artificial sweeteners and their Health
11. Implications, Biosciences Biotechnology Research Asia, 2021;18(2):227-237.
12. Petra Amchova, Hana Kotolova et.al., A Review on Health safety issues of synthetic food colorants Journal of Regulatory Toxicology and Pharmacology 2015;73(3):1-9.
13. Wissam Ghusn, Roopa Naik et.al., A Review on The Impact of Artificial Sweeteners on Human Health and Cancer Association, Journal of Cureus, 2023;15(12):1-8.
14. Rycerz K, Jaworska-Adamu JE. Effects of aspartame metabolites on astrocytes and neurons. Folia Neuropathol 2013; 51: 10-7.
15. Kavey, R.E.W. 2010. How sweet it is: sugar-sweetened beverage consumption, obesity and cardiovascular risk in childhood. Journal of the Academy of Nutrition and Dietetics. 110(10): 1456-146.
16. Clauss, K. and Jensen, H. 1970. Cycloadditionen von halogensulfonylisocyanaten an acetylene. Tetrahedron Letters 11(2): 119-122
17. Singh S, Kohli A, Trivedi S, Kanagala SG, Anamika FNU, Garg N, et al. The contentious relationship between artificial sweeteners and cardiovascular health. Egypt J Intern Med. 2023;35(1):43.
18. Sharma A, Amarnath S, Thulasimani M, Ramaswamy S. Artificial sweeteners as a sugar substitute: Are they really safe? Indian J Pharmacol. 2016;48(3):237.
19. Chattopadhyay S, Raychaudhuri U, Chakraborty R. Artificial sweeteners-a review. J Food Sci Technol. 2014;51(4):611-21.
20. Smith A, Avery A, Ford R, Yang Q, Goux A, Mukherjee I, et al. rare sugars: metabolic impacts and mechanisms of action: a scoping review. Br J of Nutr. 2022;128(3):389-406.
21. Han Y, Park H, Choi BR, Ji Y, Kwon EY, Choi MS. Alteration of Microbiome Profile by D-Allulose in Amelioration of High-Fat-Diet-Induced Obesity in Mice. Nutrients. 2020;12(2):352.
22. Saraswathy S, Mishra S. Effect of Artificial Sweeteners on the Blood Glucose Concentration. J of Med Acad. 2018;1(2):81-5.
23. Purohit V, Mishra S. The truth about artificial sweeteners – Are they good for diabetics? Indian Heart J. 2018;70(1):197-9.




