142.Issue 10 october 25 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 12, Issue : 10, October – 2025

Title:

FORMULATION DEVELOPMENT AND EVALUATION OF FLOATING TABLETS OF ALOGLIPTIN USING DIFFERENT POLYMERS

Authors :

Syed Arshad*, Dr. Rama krishna Mungi, Dr. Bigala Raj Kamal.

Abstract :

The objective of this study was to develop and evaluate floating tablets of Alogliptin using different polymers, including Acacia, Carbopol 940, and Xanthan gum. Floating drug delivery systems are designed to prolong the gastric residence time, thus enhancing drug absorption. Various formulations of Alogliptin floating tablets were prepared using the aforementioned polymers, and their pre-compression and post-compression parameters, such as tablet hardness, weight variation, friability, and floating behavior, were evaluated. Among all the formulations, formulation A2, which contained a combination of Carbopol 940 and Xanthan gum, demonstrated the most promising results in terms of floating characteristics, drug release profile. A2 formulation showed an excellent drug release of 99.61% over 12 hours, compared to other formulations. This formulation also met the acceptable limits for pre-compression and post-compression parameters, indicating its potential for optimized therapeutic performance. Based on these findings, formulation A2 was considered the most suitable and optimized formulation for floating Alogliptin tablets, providing controlled release and improved therapeutic outcomes.
Keywords: Alogliptin Floating Tablets, Acacia, Carbopol 940, and Xanthan gum.

Cite This Article:

Please cite this article in press Syed Arshad et al., Formulation Development And Evaluation Of Floating Tablets Of Alogliptin Using Different Polymers, Indo Am. J. P. Sci, 2025; 12(10).

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