Volume : 12, Issue : 10, October – 2025

Title:

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF NICARIDIPINE BY USING NATURAL POLYMERS

Authors :

Sattolla Raj Kumar*, Dr B. Manjula, Dr. Bigala Raj Kamal

Abstract :

The present study aims to formulate and evaluate mucoadhesive buccal tablets of Nicardipine, a calcium channel blocker with low oral bioavailability due to extensive first-pass metabolism. To overcome this limitation, buccal drug delivery was explored using natural polymers — Cashew nut tree gum, Xanthan gum, and Karaya gum — known for their mucoadhesive and biocompatible properties.
Tablets were prepared by direct compression and evaluated for pre-compression parameters (angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio) and post-compression parameters (hardness, friability, weight variation, surface pH, drug content, swelling index, mucoadhesive strength, and in vitro drug release). All parameters were found to be within acceptable pharmacopeial limits, indicating the suitability of the formulations.
Among all the formulations, F4 showed the most promising results, with a controlled drug release of 99.95% over 8 hours, along with excellent mucoadhesive strength and tablet stability. The study concludes that mucoadhesive buccal tablets of Nicardipine using natural polymers provide an effective alternative for enhancing bioavailability and ensuring sustained drug release, thereby improving therapeutic efficacy and patient compliance.
Keywords: Nicardipine, Cashew nut tree gum, Xanthan gum, and Karaya gum

Cite This Article:

Please cite this article in press Sattolla Raj Kumar et al., Formulation And Evaluation Of Mucoadhesive Buccal Tablets Of Nicaridipine By Using Natural Polymers , Indo Am. J. P. Sci, 2025; 12(10).

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