Volume : 12, Issue : 10, October – 2025
Title:
FORMULATION AND EVALUTION ANTIPYRETIC HERBAL CHOCOLATES FOR PEDIATRIC PURPOSE BY USING DIFFERENT PLANTS EXTRACTS.
Authors :
Manish Ahire ,Vaishnav Sawant ,Mr Sagar Vaidya Aniket Chavan ,Mrs.Sancheti V.P ,Pagar Nandkishor ,Vaishnav Mitke ,Adesh Sudke
Abstract :
Fever is one of the most frequent causes of medical consultations globally and one of the earliest clinical signs of illness in the mammalian host. One of the most common medications used to treat fevers is an antipyretic. Oral administration is among the safest ways to ensure patient compliance. Chocolate is a very complex and versatile food that may be combined to create entirely different flavors and textures. We have created a chocolate medication delivery method since chocolate is especially delicious and well-liked by children. Chocolate also has advantages, such as a rapid beginning of action, a smaller dosage of the medication, ease of production and scaling, a higher drug loading capacity, etc. A semisolid media suspended with approximately 70% fine solid sugar, cocoa, and/or milk particles makes up chocolates, which are continuous fat phases. Since ancient times, physicians in the Indian medical system have used Tamarindus indicus, Cucurbita pepo, Zingiber officinale, Mentha piperita, and Malus domestica extensively, both on their own and in combination with other drugs. The current study’s goal was to create safe and palatable antipyretic chocolate. Additionally, to assess the created formulations’ physiochemical properties in order to further standardize and commercialize them.
Keywords: Malus domestica,physiochemical,Tamarindus indicus,Chocolate,Antipyretic,pediatrics.
Cite This Article:
Please cite this article in press Manish Ahire et al., Formulation And Evalution Antipyretic Herbal Chocolates For Pediatric Purpose By Using Different Plants Extracts, Indo Am. J. P. Sci, 2025; 12(10).
REFERENCES:
1. William F Wright , Paul G Auwaerter,Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma,Volume 7, Issue 5, May 2020, ofaa132.
2. Gregorio P Milani 1,2,✉, Ilaria Alberti 1, Alessia Bonetti 3, Silvia Garattini 3, Antonio
3. Corsello 1,2, Paol Marchisio 1,3, Elena Chiappini 3,4Definition and assessment of fever-related discomfort in pediatric literature: a systematic review,2024 Sep 23;183(11):4969–4979. doi: 10.1007/s00431-024-05753-7.
4. Hussain SM, Al-Wutayd O, Aldosary AH, Al-Nafeesah A, AlE’ed A, Alyahya MS, Alfeneekh AS, AlKadi SA, Alghasham GA, Aloyaidi GA (2020) Knowledge, attitude, and practice in management of childhood fever among saudi parents. Glob Pediatr Health 7:2333794×20931613.
5. Sakr F, Toufaili Z, Akiki Z, Akel M, Malaeb D, Dabbous M, Salameh P (2022) Fever among preschool-aged children: a cross-sectional study assessing Lebanese parents’ knowledge, attitudes and practices regarding paediatric fever assessment and management. BMJ Open 12:e063013.
6.Rajashri Kulkarni*, Yogita Patil, Prajakta Kokane,Formulation and Evaluation of Herbal
Chocolate: Chocogil, INTERNATIONAL JOURNAL IN PHARMACEUTICAL
SCIENCES,Journal Homepage: https://www.ijpsjournal.com.
7.Z. K. Khan, Viraj. H. Lambhate, Rutuja R,. Jagadale, Dhanashri.T. Jawal,Formulation and evaluation of herbal chocolate from Arjuna Bark- treatment of heart diseas condition,Volume : 10, Issue : 4, Year : 2023,Article Page : 272-280.
8.Mr.Prasad Kailas Gaikwad*, 2Mr.Pratik B. Bhange, 3Dr. Megha T Salve,A Review On Formulation And Evaluation Of Pediatric Herbal Chocolate,International journal of creative research and thoughts ,IJCRT2411114.
9.Sharma, M., & Jain, D. K. (2012). Chocolate formulation as drug delivery system for Pediatrics.
Indonesian Journal of Pharmacy, 23(4), 216-224.
10.Chaudhari, S. A., Devare, R. R., Dewang, P. S., Patil, V. B., Patil, A. M., & Pawar, S. P. (2018). Review: chocolate formulation as drug delivery system. Indian Journal of Drugs, 6(2), 136-141.
11.Gravina, S. A., Yep, G. L., & Khan, M. (2013). Human Biology of Taste. Human Biology, 33(3), 217-222. https://doi.org/10.5144/0256-4947.2013.217
12.Reddy, S., Mounika, K., & Venkatesham, A. (2017). Design and fabrication of medicated chocolate formulation by chocolate drug delivery system. International Journal of Current Pharmaceutical Research, 9(5), 128-133. http://dx.doi.org/10.22159/ijcpr.2017v9i5.2215.
13.1Vikrant P. Wankhade, 2Vanshika K. Sahu, 3Rupeshri R. Netkar,Formulation and Evaluation of Nutraceutical Herbal Chocolate : Short Communication Effective Delivery of Nutraceutical by using Chocolate,© 2022 IJRAR December 2022, Volume 9, Issue 4.
14.Sunil R, Mounika K, Shalini S, Venkatesham A. Design and fabrication of medicated chocolate formulation by chocolate drug delivery system. Journal of Current Pharma Research. 2016 Oct 1;7(1):2010-20. https://doi.org/10.22159/ijcpr.2017v9i5.22156
15.Sharma M, Jain DK. Chocolate formulation as drug delivery system for paediatrics. Indonesian journal pharmacy. 2012;23(4):216-24.
16.Vasani C, Shah K. Preparation and evaluation of chocolate drug delivery system of albendazole.
Research Journal of Pharmacy and Technology. 2016;9(11):1994-8. doi:10.5958/0974360X.2016.00407.
17.Patel N, Diwan S, Shukla K, Tomar P, Jain H, Pradhan P, Upadhyay U. Chocolate drug delivery system: a review. Indo American journal of pharmaceutical sciences. 2015 Jun 1;2(6):1077-81.
18.Faccinetto-Beltrán P, Gómez-Fernández AR, Santacruz A, Jacobo-Velázquez DA. Chocolate as Carrier to Deliver Bioactive Ingredients: Current Advances and Future Perspectives. Foods. 2021 Sep 1;10(9):2065.
19.Meher SK, Das B, Panda P, Bhuyan GC, Rao MM. Uses of Withania somnifera (Linn) Dunal (Ashwagandha) in Ayurveda and its pharmacological evidences. Research journal of Pharmacology and Pharmacodynamics. 2016;8(1):23.
20.Dai J, Tao L, Shi C, Yang S, Li D, Sheng J, Tian Y. Fermentation Improves Calcium Bioavailability in Moringa oleifera leaves and Prevents Bone Loss in Calcium‐deficient Rats. Food science & nutrition. 2020 Jul;8(7):3692-703.
21. Michelfelder AJ. Soy: a complete source of protein. American family physician. 2009 Jan 1;79(1):43-7.
22.Firoj Tamboli, Harinath More. Pharmacognostic and Physicochemical analysis of Barleria gibsoni Dalz.
Pharmacophore, 2016; 7(2): 118-123.
23. Y. Saideswara Rao and K. Mary Mathew, Spices Board of India, India,Tamarind,© Woodhead Publishing Limited, 2012.
24.Gufran Ahmad1 and Abrar A. Khan2,*ISSN Number: 2572-3154Pumpkin: Horticultural Importance and Its Roles in Various Forms; a Review,international journal of horticulture and agriculture,ISSN Number: 2572-3154
25.Kankanam Gamage Chithramala Dissanayake1, Waliwita Angoda Liyanage Chandrasiri Waliwita2, Ruwan Priyantha Liyanage3,A Review on Medicinal Uses of Zingiber officinale (Ginger),International Journal of Health Sciences and Research Vol.10; Issue: 6; June 2020 .
26.Nataliia Hudz 1,2,*, Lesya Kobylinska 3, Katarzyna Pokajewicz 4, Vladimira Horčinová Sedláčková 5, Roman Fedin 6, Mariia Voloshyn 7, Iryna Myskiv 7, Ján Brindza 5, Piotr Paweł Wieczorek 4, Jacek Lipok,Mentha piperita: Essential Oil and Extracts, Their Biological Activities, and Perspectives on the Development of New Medicinal and Cosmetic Products,2023 Nov 6;28(21):7444. doi: 10.3390/molecules28217444.
27.Jiri Patocka 1, 2, , Kanchan Bhardwaj 3, Blanka Klimova , Eugenie Nepovimova 5,Qinghua Wu 5,6, Marco Landi , Kamil Kuca 1,5, * , Martin Valis 4 and Wenda Wu 5 ,Malus domestica:
A Review on Nutritional Features, Chemical Composition, Traditional and Medicinal Value,Plants 2020, 9, 1408; doi:10.3390/plants9111408 www.mdpi.com/journal/plants.
28.Arun K. Sinhaa;Upendra K. Sharmaa; Nandini Sharm,A comprehensive review on vanilla flavor: Extraction,
isolation and quantification of vanillin and others Constituents,International Journal of Food Sciences and Nutrition,June 2008; 59(4): 299-326.