Volume : 12, Issue : 10, October – 2025

Title:

PREPARATION AND EVALUATION OF ALGINATE MICROSPHERES OF LOMEFLOXACIN FOR CONTROLLED RELEASE

Authors :

Bharadwaj Simran*, Dr. K. Ramesh, Dr. Vijay Kumar Gampa, I. Nagaraju.

Abstract :

The present study aimed to develop and evaluate alginate-based microspheres of lomefloxacin for controlled drug release, with the goal of enhancing therapeutic efficacy and reducing dosing frequency. Lomefloxacin, a fluoroquinolone antibiotic, was encapsulated using the ionotropic gelation method with sodium alginate as the primary polymer and calcium chloride as the cross-linking agent. Various formulations were prepared by altering polymer concentrations and evaluated for key parameters such as particle size, entrapment efficiency, drug content, micromeritic properties, and in vitro drug release.
Among all formulations, batch F2 demonstrated optimal performance, showing high entrapment efficiency 99.31uniform particle size, and excellent flow properties. In vitro drug release studies revealed a sustained release profile over 12 hours with a cumulative drug release of 99.89 %, following Higuchi kinetics and non-Fickian diffusion mechanisms. Compatibility studies using FTIR and DSC confirmed no drug–polymer interactions, while SEM analysis indicated spherical and smooth-surfaced microspheres.
The study concludes that alginate microspheres represent a promising controlled release system for lomefloxacin, potentially improving patient compliance and therapeutic outcomes.
Keywords: Lomefloxacin Controlled release Microspheress

Cite This Article:

Please cite this article in press Bharadwaj Simran et al., Preparation And Evaluation Of Alginate Microspheres Of Lomefloxacin For Controlled Release, Indo Am. J. P. Sci, 2025; 12(10).

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