Volume : 12, Issue : 10, October – 2025
Title:
A COMPREHENSIVE REVIEW OF ADVANCES IN NANOPARTICLE BASED FORMUATION FOR CONTROLLED AND SUSTAINED DRUG DELIVERY IN SYSTEMIC THERAPY
Authors :
O.Girija kumari, J.N.Suresh Kumar, SK Mahboob Subhani, K.Sarika, M.Ramya, S.Sumathi, U.Saikrishna
Abstract :
Abstract:
Nanoparticles have revolutionized modern medicine by significantly improving drug bioavailability, targeted delivery, and controlled release mechanisms. Traditional drug delivery systems often suffer from rapid clearance, poor solubility, and systemic toxicity, leading to limited therapeutic efficacy. In contrast, nanoparticles possess unique physicochemical properties that enable precise drug targeting, thereby minimizing off-target effects and enhancing treatment outcomes.Various types of nanoparticles—such as polymeric nanoparticles, liposomes, solid lipid nanoparticles , dendrimers, and metallic nanoparticles—have been extensively investigated for drug delivery applications. These nanocarriers utilize both passive and active targeting strategies, including ligand-based functionalization, to improve therapeutic precision.A major application of nanoparticles is in oncology, where traditional chemotherapy often causes severe side effects and insufficient drug accumulation at tumor sites. Nanocarrier systems address these issues by enabling controlled drug release, improved stability, and tumor-specific delivery, thereby reducing toxicity. Moreover, photosensitizer-loaded nanoparticles have shown great promise in photodynamic therapy, offering enhanced retention and selectivity in tumor tissues. Nanoparticles are also being developed for the delivery of nucleic acids and proteins, overcoming biological barriers to improve gene therapy, RNA interference, and protein-based treatments. Biological barriers like the blood-brain barrier and mucosal layers further complicate efficient delivery.To address these limitations, current research focuses on designing biodegradable, biocompatible, and stimulus-responsive nanoparticles. Future developments are expected to integrate personalized nanomedicine, artificial intelligence, and real-time imaging technologies to further refine drug formulations and treatment strategies.This review explores emerging trends, medical applications, and the ongoing evolution of nanoparticle-based drug delivery systems. It highlights the growing importance of nanotechnology in creating precision, multifunctional, and patient-centered therapeutic solutions.
KEYWORDS: Nanotechnology, Nanoparticles, solid lipid, targeted delivery
Cite This Article:
Please cite this article in press O.Girija kumari et al., A Comprehensive Review Of Advances In Nanoparticle Based Formuation For Controlled And Sustained Drug Delivery In Systemic Therapy, Indo Am. J. P. Sci, 2025; 12(10).
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