61.Issue 10 october 25 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 12, Issue : 10, October – 2025

Title:

DESIGN, DEVELOPMENT, AND APPLICATIONS OF GASTRO-RETENTIVE FLOATING DRUG DELIVERY SYSTEM: AN UPDATED REVIEW

Authors :

Juweria Fatima, Lubna Nousheen*, Mohammad Shamim Qureshi

Abstract :

Gastro-retentive floating drug delivery systems (GRFDDS) have emerged as a pivotal strategy in the design of oral sustained release formulations. These systems aim to improve the bioavailability and therapeutic efficacy of drugs by increasing their gastric residence time. GRFDDS are particularly beneficial for drugs that are poorly soluble in the alkaline pH of the intestine, drugs with a narrow absorption window in the upper gastrointestinal tract (GIT), and those intended for local action in the stomach. Various techniques, including effervescent and non-effervescent mechanisms, have been employed to ensure the buoyancy of the dosage form. The present review provides an updated and critical insight into the design principles, formulation strategies, polymers and excipients used, evaluation techniques, and current clinical applications of GRFDDS. Moreover, recent advancements, challenges, and future prospects are discussed to understand the evolving role of these systems in drug delivery science.
Keywords: Gastro-retentive drug delivery system, Floating dosage forms, Buoyancy, Controlled release, Gastric residence time.

Cite This Article:

Please cite this article in press Lubna Nousheen et al., Design, Development, And Applications Of Gastro-Retentive Floating Drug Delivery System: An Updated Review, Indo Am. J. P. Sci, 2025; 12(10).

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