Volume : 12, Issue : 10, October – 2025

Title:

A CASE REEPORT ON ZOLEDRONIC ACID INDUCED GAIT ABNORMALITY IN PATIENT WITH PROSTATE CANCER WITH SECONDARY BONE METASTASIS.

Authors :

Sireesha Katta, ,Dr. T V Siva Rama Krishna, Dr.Venkata Rama Rao Nallani

Abstract :

Introduction: Perennial zoledronic acid infusions can lead to nitrogen-based bisphosphonate- related structural change in legs, leads bow leg bone deformities. ZOL’s high affinity for the hydroxyapatite crystals found in bones through a high turnover process slows down bone remodelling ,on prolong use of perennial zoledronic increase the brittleness of bone reduced capacity to heal skeletal microfractures .This drug is internalised by osteoclasts, which speeds up the occurrence of apoptosis, and affects the metabolism and activity of osteoclast cells during the process of bone resorption.
Case presentation: A 60-year-old male patient diagnosed with Stage IIA Prostate cancer with bone metastasis who is currently on Zoledronic acid Infusion and complains of unsteady gait due to terrible pain in both legs and with swollen knee joints. The gait abnormalities are prominent in lower limbs.
Conclusion: Long-term use of zoledronate perennial infusions has been interrelated with bow leg deformities due to Over suppression of Bone Turnover which further associated to cause frozen bone is particularly common in patients with bone metastasis.

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