80.Issue 10 october 25 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 12, Issue : 10, October – 2025

Title:

EVALUATION OF THE ANTIULCER ACTIVITY OF METHANOLIC EXTRACT OF THE LEAVES OF AZADIRACHTA INDICA A. JUSS IN RATS

Authors :

Dandu Ahalya*, Mrs. Geetha Vani, Dr. D. Venkata Ramana

Abstract :

The antiulcer activity of ethanolic extract of Azadirachta indica a. juss leaves (EEAI) was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Ethanolic extract of Azadirachta indica a. juss at a dose of 150 and 300mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (150mg/kg and 300mg/kg) showed significant (p<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that EEAI have potential anti-ulcer activity in both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity
Key words Azadirachta indica a. juss, antisecretory, cytoprotective, gastric ulcer, ethanol induced ulcers and pylorus ligation induced ulcers.

Cite This Article:

Please cite this article in press Dandu Ahalya et al., Evaluation of the antiulcer activity of methanolic extract of the leaves of azadirachta indica a. Juss in rats, Indo Am. J. P. Sci, 2025; 12(10).

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