Volume : 12, Issue : 10, October – 2025
Title:
FORMULATION AND EVALUATION OF XANTHAN GUM MICROSPHERES FOR THE SUSTAINED RELEASE OF FLURBIPROFEN
Authors :
Dhumala Ruthisha*, M. Mounika, Dr. D. Venkata ramana.
Abstract :
The aim of the study was to prepare Flurbiprofen microspheres using Solvent evaporation method using different polymer ratio. FT-IR studies revealed that there was no chemical interaction between the drug and polymer. The average particle size of the optimized formulation was found to be 166 μm. The in-vitro release behavior from all the Nifedipine microspheres was found to be peppas drug release kinetics and produced a sustained release over a period of 12 hours with better entrapment efficiency.
Key words: Flurbiprofen, Carbopol 934p, Xanthan Gum, Solvent evaporation method and microspheres.
Cite This Article:
Please cite this article in press Dhumala Ruthisha et al., Formulation And Evaluation Of Xanthan Gum Microspheres For The Sustained Release Of Flurbiprofen , Indo Am. J. P. Sci, 2025; 12(10).
REFERENCES:
1. Kadam N. R. and Suvarna V. Microspheres: A Brief Review. Asian Journal of Biomedical and Pharmaceutical Sciences, 2015.
2. Patel N. R., Patel D. A., Bharadia P.D., Pandya V., Modi D.,Microsphere as a novel drug delivery, Int. j. pharm. life sci. 2011;2(8):992-7.
3. Singh C., Purohit S., Singh M., Pandey B.L., Design and evaluation of microspheres: A Review, jddr. 2013;2(2):18-27.
4. Prasanth v.v., Moy A. C., Mathew S. T., Mathapan R., MicrospheresAn overview, Int. J. Res. Pharm. Biomed. Sci., 2011;2:3328.
5. Sree Giri Prasad B., Gupta V. R. M., Devanna N., Jayasurya K., Microspheres as drug delivery system – A review, JGTPS. 2014;5(3): 1961 -72.
6. Mohan M., Sujitha H., Dr. Rao V. U. M., Ashok M., Arun kumar B., A brief review on mucoadhesive microspheres, IJRRPAS.2014;4(1):975-86.
7. Kumar A., Jha S., Rawal R., Chauhan P.S., Maurya S. D., Mucoadhesive microspheres for novel drug delivery system: A Review, Am. J. Pharm Tech Res.2013;3(4):197-213.
8. Thummar A.V., Kyada C.R., Kalyanvat R., Shreevastva B., A review on mucoadhesive microspheres as a novel drug delivery system, International Journal for Pharmaceutical Research Scholars.2013;2(2):188-200.
9. Mukherjee S., Bandyopadhyay P., Magnetic microspheres: A latest approach in novel drug delivery system, JPSI. 2012;1(5):21-25.
10. Batra D., Kakar S., Singh R., Nautiyal U.,Magnetic microspheres as a targeted drug delivery system:An overview, Jddr. 2012;1(3):1-17.
11. Dutta P., Sruti J., Patra Ch. N., Rao M. E. B.,Floating microspheres: Recent trends in the development of gastrorententive floating drug delivery system, Int. J. Pharm. Sci. Nanotech. 2011;4(1):1296-1306.
12. Mukund J. Y., Kantilal B. R., Sudhakar R. N., Floating microspheres: A review, Braz. J. Pharm. Sci. 2012;48(1):17-30.
13. Kawatra M., Jain U., Ramana J., Recent advances in floating microspheres as gastro-retentive drug delivery system: A review, IJRAPR. 2012;2(3):5-23.
14. Ramteke K.H., Jadhav V.B., Dhole S.N., Microspheres: As carrieres used for novel drug delivery system, IOSRPHR. 2012;2(4):44-48.
15. Dupinder K., Seema S., Gurpreet S., Rana A.C., Biodegradable microspheres: A review, IRJP.2012; 3(12):23-27.
16. Saralidze K., Koole L.H., Knetsch M. L. W., Polymeric microspheres for medical applications, Materials. 2010;3:3537-64.
17. Patel B., Modi V., Patel K., Patel M., Preparation and evaluation of ethyl cellulose microspheres prepared by emulsifica tion – solvent evaporation method, International Journal For Research In Management And Pharmacy. 2012;1(1):83-91.
18. . Bansal H., kaur S. P., Gupta A. K., Microsphere: Methods of preparation and applications;A comparative studPharm Sci Rev Res. 2011;10(1):69-78.
19. Alagusundaram M., Chetty.C. M. S., Umashankari.K, Badarinath A. V., Lavanya.C., Ramkanth.S., Microspheres as a novel drug delivery sytem- A review, Int J ChemTech Res. 2009;1(3):526-34.
20. Sahil K., Akanksha M., Premjeet S., Bilandi A., Kapoor B., Microsphere: A review. Int. J. Res. Pharm. Chem., 2011;1:1184- 98
21. Pavan Kumar B., Chandiran I. S., Bhavya B., Sindhuri M., Microparticulate drug delivery system: A Review, Indian journal of pharmaceutical science & research, 2011;1(1):19-37.
22. Alagusundaram.M, Madhu Sudana Chetty.C, Umashankari.K, Attuluri Venkata Badarinath, Lavanya.C and Ramkanth.S. Microspheres as a novel drug delivery system – a review. Vol.1, No.3 , pp 526-534, July-Sept 2009.
23. Sahil K., Akanksha M., Premjeet S., Bilandi A., Kapoor B., Microsphere: A review. Int. J. Res. Pharm. Chem., 2011;1:1184-98
24. Pavan Kumar B., Chandiran I. S., Bhavya B., Sindhuri M., Microparticulate drug delivery system: A Review, Indian journal of pharmaceutical science & research, 2011;1(1):19-37.
25. Mali D.S., Talele S. G., Mogal R., Chaudhari G., Review on nasal microspheres, Am. J. Pharm Tech Res. 2014;4(1):97-111.
26. Patibandla Jahnavi, Arpitha G, Vishal Shah, Sudhir S Hunge, S. Manodhini elakkiya, Rajesh KS, Sangeetha P.T. and Shivanand Hiremath. Formulation and Evaluation of Sustained Release Microspheres for Anti-Diabetic Drug Delivery. SEEJPH Volume XXV, 2024, ISSN: 2197-5248.
27. Akshay. M. Akotkar, Ashwini. A. Zanke, Kuldip V. Gite. Formulation And Evaluation Of Oral Microspheres Containing Antihypertensive Drugs By Emulsion Solvent Evaporation Method. Vol. 30 No. 05 (2023): JPTCP (635-645).
28. Shazia Akram Ghumman, Arshad Mahmood, Sobia Noreen, Mavra Rana, Huma Hameed, Bushra Ijaz, Sara Hasan c, Afeefa Aslam,Muhammad Fayyaz ur Rehman. Volume 15, Issue 6, June 2022, 103811.
29. Manikandan Palanivelu, Aswathi Prashob, Nethaji Ramalingam, Surendra Kumar Muniyandi. Formulation and Evaluation of Ranitidine Hydrochloride Loaded Floating Microspheres for the Treatment of Gastric Ulcer. International Journal of Current Science research and review, volume 04 issue 08 august 2021.
30. Kauslya arumugam, payal d. Borawake1, jitendra v. Shinde. Formulation And Evaluation Of Floating Microspheres Of Ciprofloxacin By Solvent Evaporation Method Using Different Polymers. Int J Pharm Pharm Sci,2021, Vol 13, Issue 7, 101-108.