Volume : 12, Issue : 10, October – 2025
Title:
FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF EXTENDED-RELEASE TABLETS CONTAINING TENATOPRAZOLE SODIUM
Authors :
Vuyyuru Bindu Naga Sai Tejaswi*, P. Umadevi, Dr. D. Venkata ramana.
Abstract :
The present study focuses on the formulation development and in-vitro evaluation of extended-release tablets containing Tenatoprazole Sodium, utilizing a combination of various polymers, including Carbopol, Hydroxypropyl Methylcellulose (HPMC), and Xanthan Gum. The aim was to achieve sustained and controlled drug release over a period of 12 hours, ensuring therapeutic efficacy with minimal dosing frequency. Different formulations were prepared by varying the concentrations of these polymers to optimize the drug release profile. In-vitro release studies were conducted, and the release pattern was evaluated using a standard dissolution test. Among all the formulations, formulation T2 exhibited the most favorable drug release profile, releasing 99.82% of Tenatoprazole Sodium over the 12-hour period. Based on its consistent and near-complete drug release, formulation T2 was considered the optimized formulation. The results demonstrate the potential of these polymer combinations to effectively control the release of Tenatoprazole Sodium and improve patient compliance in the treatment of gastrointestinal conditions.
Keywords: Tenatoprazole Sodium , Extended release Tablets
Cite This Article:
Please cite this article in press Vuyyuru Bindu Naga Sai Tejaswi et al., Formulation Development And In-Vitro Evaluation Of Extended-Release Tablets Containing Tenatoprazole Sodium, Indo Am. J. P. Sci, 2025; 12(10).
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