Volume : 12, Issue : 10, October – 2025
Title:
PREPARATION AND EVALUATION OF PALONOSETRON ORODISPERSIBLE FILMS USING POLYVINYL ALCOHOL, MALTODEXTRIN AND PROPYLENE GLYCOL
Authors :
Karrem Nisha, Chandrasekhara Rao Baru*, Sushma Desai, Katroth Jithender
Abstract :
Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is used for the control of delayed CINV—nausea and vomiting and there are tentative data to suggest that it may be more effective than granisetron. Present work aimed at preparing quick onset of action which is beneficial in hypertension, aiding in the bioavailabity enhancement and its convenience for administration. The film was prepared by using polymers Polyvinyl alcohol, Maltodextrin and Propylene glycol by a solvent casting method. They were evaluated for physical characteristics such as Thickness, Weight Variation, Disintegration time, Drug content, Tensile strength, % Elongation, Folding Endurance and Invitro Dissolution Studies give satisfactory results. The in vitro disintegration time and dissolution time of the optimized batch F4 was found to be14 sec and 98.97% respectively.
Keywords: Palonosetron, bioavailability, oral fast dissolving films.
Cite This Article:
Please cite this article in press Chandrasekhara Rao Baru et al., Preparation And Evaluation Of Palonosetron Orodispersible Films Using Polyvinyl Alcohol, Maltodextrin And Propylene Glycol, Indo Am. J. P. Sci, 2025; 12(10).
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