Volume : 12, Issue : 09, September – 2025
Title:
ANTIMICROBIAL AND ANTI ACNE ACTIVITY OF BALANITES AEGYPTIACA
Authors :
Mr. Vivek Thakur, Pragya Mishra, B. K. Dubey, Deepak Kumar Basediya, Prabhat Kumar Jain
Abstract :
This study investigates the therapeutic potential of the hydroalcoholic extract of Balanites aegyptiaca in treating acne induced by Propionibacterium acnes in a rat model. The hydroalcoholic extract demonstrated a higher yield (6.20% w/w) compared to the pet ether extract (0.85%), indicating that this extraction method is more efficient in obtaining bioactive compounds. Phytochemical analysis revealed the presence of alkaloids, flavonoids, proteins, and saponins, which are known for their antimicrobial, anti-inflammatory, and immunomodulatory properties, suggesting their role in acne treatment. The extract showed moderate antimicrobial activity with a zone of inhibition of 14 mm against Propionibacterium acnes at 100 mg/ml, though less potent than Clindamycin, which exhibited a 21 mm zone at 30 μg/ml. In vivo, the hydroalcoholic extract significantly reduced skin thickness in rats treated with doses of 100 mg/kg and 200 mg/kg, with the higher dose demonstrating more pronounced effects. These results suggest that the extract’s antimicrobial and anti-inflammatory properties contribute to its potential as an acne treatment. Although Clindamycin was more effective, the hydroalcoholic extract of Balanites aegyptiaca presents a promising natural alternative for acne treatment, particularly for individuals seeking plant-based options. This study underscores the therapeutic value of alkaloids and saponins in the extract and highlights its potential for further clinical exploration in human acne therapy.
Keywords: Balanites aegyptiaca, hydroalcoholic extract, acne, Propionibacterium acnes, antimicrobial activity, hytochemical screening, Clindamycin, skin thickness, anti-inflammatory properties, natural remedies, acne treatment, bioactive compounds.
Cite This Article:
Please cite this article in press Pragya Mishra et al., Antimicrobial And Anti Acne Activity Of Balanites Aegyptiaca., Indo Am. J. P. Sci, 2025; 12(09).
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