Volume : 12, Issue : 09, September – 2025
Title:
A REVIEW ON FORMULATION AND CHARACTERIZATION OF OCTREOTIDE MICROSPHERES
Authors :
Dr. M Vara Lakshmi, Aruna Kumari.K*,Bhavya Tejaswi.G, Jithendra Laxman Sai,Surya Kiran .M
Abstract :
The long-acting release (LAR) formulation of the somatostatin analogue octreotide, known as octreotide microspheres, has greatly enhanced the therapeutic treatment of hormone-related conditions such neuroendocrine tumors and acromegaly. The development, formulation techniques, pharmacokinetics, clinical effectiveness, and safety profile of octreotide microspheres are highlighted in this study. These microspheres, which use biodegradable polymers, mainly poly(lactic-co-glycolic acid) (PLGA), allow for persistent drug release after monthly intramuscular treatment. This provides a significant benefit over short-acting preparations in terms of therapeutic consistency and patient compliance. Clinical research shows how well they work to decrease overproduction of hormones, lessen symptoms associated with tumors, and enhance quality of life. Although usually well accepted, it is crucial to pay attention to possible side effects such changes in glucose metabolism, gallbladder issues, and gastrointestinal problems. In order to better optimize long-term treatment results, this study examines current developments in delivery technologies and highlights the therapeutic utility of octreotide microspheres.
Keywords: Octreotide microspheres; Long-acting release (LAR); PLGA; Neuroendocrine tumors; Drug delivery; Therapeutic efficacy.
Cite This Article:
Please cite this article in press Aruna Kumari.K et al., A Review On Formulation And Characterization Of Octreotide Microspheres., Indo Am. J. P. Sci, 2025; 12(09).
REFERENCES:
1. Krishnakant N, Kiran CVS. R and Kuchana V. Formulation and evaluation of gastro retentive drug delivery system of Diltiazem hydrochloride. Int J Res Pharmacy Chem. 2015; 5(4): 597-606.
2. Kadam N. R., Suvarna V. Microspheres: A Brief Review. Asian J of Biomedical and Pharmaceutical Sci, 5(47); 2015: 13-19.
3. Joseph S and Selvin CDS. Formulation and evaluation of losartan microspheres. Int J Res Pharmacy Chem. 2015; 5(4): 555-563.
4. Sharma N, Purwar N and Gupta PC. Microspheres as drug carriers for controlled drug delivery: a review. Int J Pharm Sci Res. 2015; 6(11): 4579-4578.
5. Vetal S, Varma MM and Abulu K. Formulation & evaluation of sustained release microspheres of propranolol. World Journal Pharmacy Pharmaceutical Sci. 2017; 6(11): 1497-1507.
6. Kalinidhi DV. Microspheres of Diltiazem hydrochloride by ionotropic gelation technique. Int J Pharm Sci Res. 2017; 8(3): 1413-1419.
7. Guiot P, Couvreur P. Polymeric Nanoparticles and Microspheres. New York, USA: CRC Press; 1986. p. 207.
8. Chein YW. Oral Drug Delivery Systems: In Novel Drug Delivery Systems. Vol. 50. New York: Marcel Dekker, Inc.; 1992. p. 139-77.
9. Vyas SP, Khar RK. Targeted and Controlled Drug Delivery. 7th ed. New Delhi, India: Vallabh Prakash An;1990. p. 418.
10. Brahmana DM, Jaiswal SB. Biopharmaceutics and Pharmacokinetics. 2nd ed. New Delhi, India: Vallabh Prakash An; 2009. p. 488.
11. Prasanth VV, Moy AC, Mathew ST, Mattapan R. Microspheres-an overview. Int J Res Pharm Biomed Sci 2011;2:332-8.
12. Sahil K, Akanksha M, Premjeet S, Bilandi A, Kapoor B. “Microspheres”: A review. Int J Res Pharm Chem 2011;1:1184-98.
13. Meena KP, Dangi JS, Samal PK, Namdev KP. Recent advances in microspheres manufacturing technology. Int Pharm Technol 2011;3:854-93.
14. Urs AV, Kavitha K, Sockman GN. Albumin microspheres: “A unique system as drug delivery carriers for nonsteroidal anti-inflammatory drugs (NSAIDs). Int J Pharm Sci Rev Res 2010;5:10-7.
15. Bansal H, Kaur SP, Gupta AK. “Microspheres”: Methods of preparation and applications; a comparative study. Int J Pharm Sci Rev Res 2011;10:69-78.
16. Thanou M, Niwot MT, Jansen M, Verhoef JC, Junginger HE. Mono-N-carboxy methyl chitosan (MCC), a polyampholyte chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo. Pharm Sci 2001;90:38-46.
17. Vyas SP, Khar RK. Targeted and Controlled Drug Delivery. 7th ed. New Delhi, India: Vallabh Prakash An; 2010. p. 420-45.
18. Alagusundaram M. Microspheres as a novel drug delivery system-a review. Int J Chemtech Res 2009;1:526.
19. Bhai MS, Yadav V, Mamatha Y, Prasanth VV. Mucoadhesive microsphere an overview. Am J Pharmtech Res 2012;2:237-58.
20. Liu G, Yang H, Zhou J, Law SJ, Jiang Q, Yang G. Preparation of magnetic microsphere from water-inoil emulsion stabilized by block copolymer dispersant. Biomacromolecules 2005;6:1280-8.
21. Lachman LA, Liberman HA, Karnig JL. The Theory and Practice of Industrial Pharmacy. 3rd ed. Mumbai, India: Varghese Publishing House; 1991. p. 414-5.
22. Amsden BG, Goosen M. An examination of factors affecting the size, distribution and release characteristics of polymer microbeads made using electrostatics. J Control Release 1997;43:183-96.
23. Ramteke K.H., Jadhav V.B., Dhole S.N., Microspheres: As carrieres used for novel drug delivery system, IOSRPHR, 2012; 2(4): 44-48.
24. Farooqui Mohd Shafeuddin*A REVIEW ON MICROSPHERES Vol 12, Issue 2, 2023.
25. Dandarid PM, Mastiholimath VS, Patil MB, Gupta MK. Biodegradable microparticulate system of captopril. Int J Pharm 2006;307:83-88.
26. V. Gulghane, Sunita N. Vaidya, V. Satote, S. Waghde, S. Kale, A REVIEW ON MICROSPHERES AS DRUG CARRIERS, Asian Journal of Pharmaceutics • Jul-Sep 2024 • 18 (3) | 800-807.
27. https://www.mayoclinicproceedings.org/article/S0025-6196(21)00845-4/fulltext
28. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/octreotide
29. https://en.wikipedia.org/wiki/Octreotide#/media/File:Octreotide.svg